Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France.
CEA DAM, GRAMAT, F-46500, Gramat, France.
Sci Rep. 2019 Oct 25;9(1):15324. doi: 10.1038/s41598-019-51686-9.
High power electromagnetic signals can disrupt the functioning of electronic devices. As electromagnetism plays a role in cells homeostasis, such electromagnetic signals could potentially also alter some physiological processes. Herein we report on distinct biological parameters assessment after cellular spheroids exposure to high power electromagnetic signals, such as the ones used for defense applications. Signals effects were assessed in tumor cells spheroids and in normal human dermal fibroblasts spheroids, where macroscopic aspect, growth, plasma membrane integrity, induction of apoptosis, ATP content, and mitochondrial potential were investigated after spheroids exposure to high power electromagnetic signals. No significant effects were observed, indicating that 1.5 GHz narrowband electromagnetic fields with incident amplitude level of 40 kV/m, and 150 MHz moderate-band electric fields with an amplitude of 72.5 to approximately 200 kV/m, do not cause any significant alterations of assessed parameters.
高功率电磁信号可能会干扰电子设备的正常运行。由于电磁在细胞内环境稳定中发挥着重要作用，这些电磁信号也可能会改变某些生理过程。在此，我们报告了细胞球体暴露于高功率电磁信号（例如用于防御应用的电磁信号）后，对其进行评估得到的不同生物学参数。在肿瘤细胞球体和正常人类真皮成纤维细胞球体中，研究了球体暴露于高功率电磁信号后宏观形态、生长、质膜完整性、细胞凋亡诱导、ATP 含量和线粒体膜电位等方面的变化。结果没有观察到明显的影响，表明 1.5GHz 窄带电磁信号（入射幅度为 40kV/m）和 150MHz 中频带电场（幅度为 72.5 至约 200kV/m）不会导致评估参数发生任何显著变化。
