Department of Stomatology, Zhenjiang First people's Hospital Affiliated to Jiangsu University, Zhenjiang, China.
Department of Stomatology, Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing, China.
J Oral Pathol Med. 2021 Mar;50(3):308-315. doi: 10.1111/jop.12968. Epub 2020 Feb 28.
Long non-coding RNAs (lncRNAs) have been shown to be aberrantly expressed in oral squamous cell carcinoma (OSCC), but the biological role and function of BRAF-activated long non-coding RNA (BANCR) in OSCC remain poorly understood. In this study, we found that the expression of BANCR was upregulated in OSCC tissues and cell lines compared to the negative control. The decreased expression of BANCR in vitro markedly inhibited OSCC cell proliferation, migration, and invasion while the opposite was observed for the overexpression of BANCR. The results also showed that the expression of MAPK signaling-related proteins (p-erk, p-akt, and p-p-38) was positively correlated with that of BANCR. Thus, BANCR may play an important role in the tumorigenesis of OSCC, as well as cell proliferation, migration, and invasion of OSCC, and it may be a potential therapeutic target and prognostic factor in OSCC patients.
长链非编码 RNA（lncRNAs）在口腔鳞状细胞癌（OSCC）中表现出异常表达，但 BRAF 激活的长链非编码 RNA（BANCR）在 OSCC 中的生物学作用和功能仍知之甚少。在这项研究中，我们发现 BANCR 的表达在 OSCC 组织和细胞系中上调，与阴性对照相比。BANCR 在体外的表达下调显著抑制了 OSCC 细胞的增殖、迁移和侵袭，而 BANCR 的过表达则观察到相反的结果。结果还表明，MAPK 信号相关蛋白（p-erk、p-akt 和 p-p-38）的表达与 BANCR 的表达呈正相关。因此，BANCR 可能在 OSCC 的肿瘤发生以及 OSCC 细胞的增殖、迁移和侵袭中发挥重要作用，它可能是 OSCC 患者的潜在治疗靶点和预后因素。
