Department of Immunology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Ann Allergy Asthma Immunol. 2020 Jan;124(1):57-69. doi: 10.1016/j.anai.2019.10.014. Epub 2019 Oct 22.
During the last decade, several studies have evaluated the potential association between vitamin D receptor (VDR) gene polymorphism and susceptibility to asthma. In spite of valuable findings, the results are still contradictory. Therefore, a comprehensive meta-analysis not only solves discrepancies but provides a clue for future projects.
This meta-analysis was performed to identify whether VDR gene polymorphisms (FokI (rs2228570) or TaqI (rs731236) or BsmI (rs1544410) or ApaI (rs7975232)) play a role in the risk of asthma.
Electronic search of Web of Science, Scopus, and PubMed databases were systematically conducted from their inception until June 2019, to identify all published studies. Eligibility of the studies was confirmed by precise inclusion and exclusion criteria, and the resultant studies were analyzed.
A total of 17 studies concerning VDR gene polymorphisms and asthma risk were included in this meta-analysis. The results of pooled analysis indicated a statistically significant association between FokI SNP (dominant model [OR = 0.78, 95% CI, 0.62-0.98, random effect model] and allelic model [OR = 0.81, 95% CI, 0.67-0.98, random effect model]) and TaqI SNP (homozygote contract model [OR = 0.70, 95% CI, 0.54-0.89]) with asthma risk. Moreover, subgroup analysis showed that ethnicity influences asthma risk in Asian, African, and American populations. The sensitivity analyses confirmed the stability of the results.
This meta-analysis suggests that VDR gene polymorphism is associated with the risk of asthma.
在过去的十年中，已有多项研究评估了维生素 D 受体（VDR）基因多态性与哮喘易感性之间的潜在关联。尽管有重要发现，但结果仍存在争议。因此，全面的荟萃分析不仅可以解决差异，还可以为未来的项目提供线索。
本荟萃分析旨在确定 VDR 基因多态性（FokI（rs2228570）或 TaqI（rs731236）或 BsmI（rs1544410）或 ApaI（rs7975232））是否在哮喘风险中起作用。
系统地检索了 Web of Science、Scopus 和 PubMed 数据库，从其成立之初到 2019 年 6 月，以确定所有已发表的研究。通过精确的纳入和排除标准确认研究的合格性，并对纳入的研究进行分析。
共有 17 项关于 VDR 基因多态性与哮喘风险的研究纳入本荟萃分析。汇总分析结果表明，FokI SNP（显性模型[OR=0.78，95%CI，0.62-0.98，随机效应模型]和等位基因模型[OR=0.81，95%CI，0.67-0.98，随机效应模型]）和 TaqI SNP（纯合子合同模型[OR=0.70，95%CI，0.54-0.89]）与哮喘风险存在统计学显著关联。此外，亚组分析表明，种族会影响亚洲、非洲和美洲人群的哮喘风险。敏感性分析证实了结果的稳定性。
本荟萃分析表明，VDR 基因多态性与哮喘风险相关。
