School of Materials Science and Engineering, Wuhan Institute of Technology, Guanggu 1st road, Wuhan, 430205, People's Republic of China.
Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan, 430079, People's Republic of China.
Biol Trace Elem Res. 2020 Aug;196(2):494-501. doi: 10.1007/s12011-019-01928-8. Epub 2019 Oct 26.
The purpose of this research is to investigate the absorption, distribution, excretion, and pharmacokinetics of selenite in rats after intragastric administration, and thus illustrate the efficiency of selenium (Se) supplementation. After a single gavage of sodium selenite, a concentration of Se in plasma and tissues was determined by inductively coupled plasma mass spectrometry (ICP-MS) at different time points. Through fitting the data with the metabolic kinetic model, the corresponding kinetic parameters were determined for plasma and tissues, including kidney, liver, heart, muscle, and gonad. While the metabolic kinetics of sodium selenite in plasma, liver, and kidney of rats was well reflected by a two-compartment open model, that in heart and gonad was fitted to a one-compartment open model, and that in muscle was fitted to a one-compartment open model with a lag time. The results indicate that sodium selenite was absorbed by plasma and tissues quickly and was eliminated slowly after intragastric administration. Based on the results, we propose that multi-supplementation of Se with low dosage is superior to single supplementation with high dosage, in terms of avoiding selenosis.
本研究旨在探讨亚硒酸钠经灌胃给予大鼠后在体内的吸收、分布、排泄和药代动力学，从而说明硒（Se）补充的效率。在单次给予亚硒酸钠后，在不同时间点通过电感耦合等离子体质谱法（ICP-MS）测定血浆和组织中的硒浓度。通过将数据拟合到代谢动力学模型中，确定了血浆和组织（包括肾脏、肝脏、心脏、肌肉和性腺）的相应动力学参数。虽然血浆、肝脏和肾脏中亚硒酸钠的代谢动力学很好地反映了双室开放模型，但心脏和性腺的代谢动力学则拟合为一室开放模型，而肌肉的代谢动力学则拟合为具有滞后时间的一室开放模型。结果表明，亚硒酸钠经灌胃给予后被血浆和组织快速吸收，排泄缓慢。基于这些结果，我们提出，与高剂量单一补充相比，低剂量多补充 Se 可以避免硒中毒。
