Gulsvik A, Fagerhol M K
Scand J Respir Dis. 1979 Oct;60(5):267-74.
In a community survey in Oslo, Norway, comprising 1268 persons, alpha 1-antitrypsin concentration in serum (AT) and protease-inhibitor (Pi) phenotypes were examined in 1258 subjects. Estimated percentage distribution of Pi-phenotypes in the target population aged 15--70 years was M 87.30%, MS 4.65%, MZ 4.73%, FM 2.69%, SZ 0.13%, IM 0.20%, FZ 0.07%, S 0.06%, FS 0.07% and Z 0.06%. The distribution curve of AT had a normal (Gaussian) shape and the ranges of AT demonstrated great overlap of types MS and MZ with type M. In subjects with phenotype MZ neither respiratory symptoms nor physicians' diagnoses of chronic obstructive lung disease (COLD) were more frequent than in M subjects. Physicians' diagnoses of COLD were slightly more frequent (0.06 greater than P greater than 0.01) in subjects with phenotype MS than M, probably due to there being more smokers in the MS group. Spirometric variables given as per-cent of predicted values yielded large differences between smokers and non-smokers but no differences among phenotypes M, MS and MZ. Radiologic signs of hypertransradiancy and/or emphysema were evently distributed in M, MS and MZ subjects. The only subject observed with Pi-type Z and one out of three subjects with type SZ had COLD. In neither smokers nor non-smokers is phenotype MZ a risk factor of clinical importance for development of obstructive lung disease.
在挪威奥斯陆开展的一项涵盖1268人的社区调查中，对1258名受试者的血清α1 -抗胰蛋白酶浓度（AT）和蛋白酶抑制剂（Pi）表型进行了检测。在15至70岁的目标人群中，Pi表型的估计百分比分布为：M型87.30%、MS型4.65%、MZ型4.73%、FM型2.69%、SZ型0.13%、IM型0.20%、FZ型0.07%、S型0.06%、FS型0.07%以及Z型0.06%。AT的分布曲线呈正态（高斯）形状，且AT的范围显示MS型和MZ型与M型有很大重叠。在MZ型表型的受试者中，呼吸道症状以及医生诊断的慢性阻塞性肺疾病（COLD）并不比M型受试者更常见。与M型受试者相比，MS型表型的受试者中医生诊断的COLD略为常见（0.06＞P＞0.01），这可能是因为MS组中有更多吸烟者。以预测值百分比表示的肺功能测定变量在吸烟者和非吸烟者之间存在很大差异，但在M型、MS型和MZ型表型之间没有差异。透亮度增加和/或肺气肿的放射学征象在M型、MS型和MZ型受试者中分布均匀。观察到的唯一一名Pi - Z型受试者以及三名SZ型受试者中的一名患有COLD。无论是吸烟者还是非吸烟者，MZ型表型都不是阻塞性肺病发生的具有临床重要性的危险因素。
