Ostrow D N, Manfreda J, Dorman T, Cherniack R M
Can Med Assoc J. 1978 Mar 18;118(6):669-72.
To determine whether persons with intermediate value alpha1-antitrypsin phenotypes living in a polluted environment manifest significant abnormalities in lung function, a study was undertaken of an age-, sex- and smoking-stratified sample of 391 persons from the town of Fort Frances, Ont., which has elevated values of total dustfall, suspended particulates and hydrogen sulfide. Indices of pulmonary function were derived from the maximum expiratory flow and the single breath expiratory flow and the single breath expiratory nitrogen washout curves. The percentage frequency of the M, MS and MZ pheontypes was 91.7, 7.3 and 0.8, respectively. There was no significant difference between the M and MS groups as indicated by the nitrogen washout curve and maximum expiratory flow curve. There was no significant difference between the three MZ subjects and the M group. In both M and MS groups smokers displayed evidence of airflow obstruction when compared with nonsmokers. It would appear that, when compared with M subjects, persons with the MS phenotype living in a moderately polluted area show no changes in indicators of pulmonary function, including tests of early airway disease, that cannot be attributed to their smoking habit.
为了确定生活在污染环境中的具有中间值α1-抗胰蛋白酶表型的人是否在肺功能方面表现出显著异常，对安大略省弗雷斯诺堡镇的391人进行了一项研究，该样本按年龄、性别和吸烟情况分层，该镇的总降尘、悬浮颗粒物和硫化氢值升高。肺功能指标来自最大呼气流量、单次呼吸呼气流量和单次呼吸呼气氮洗脱曲线。M、MS和MZ表型的百分比频率分别为91.7%、7.3%和0.8%。氮洗脱曲线和最大呼气流量曲线表明，M组和MS组之间没有显著差异。三名MZ受试者与M组之间也没有显著差异。在M组和MS组中，吸烟者与不吸烟者相比均显示出气流阻塞的迹象。与M表型的人相比，生活在中度污染地区的MS表型的人在肺功能指标方面似乎没有变化，包括早期气道疾病测试，这些变化不能归因于他们的吸烟习惯。
