From the Department of Pathology, University of Michigan, Ann Arbor.
Arch Pathol Lab Med. 2019 Nov;143(11):1332-1337. doi: 10.5858/arpa.2019-0375-RA.
CONTEXT.—: Leiomyosarcoma of bone is a rare primary osseous sarcoma characterized by smooth muscle differentiation and absence of malignant osteoid formation. Leiomyosarcoma of bone is diagnostically challenging; this can be improved with greater awareness of this entity and the ability to differentiate it from its histologic mimics. Because of its rarity, only a small number of studies are available in the literature. These factors contribute to our limited understanding of its pathology, prognosis, and treatment.
OBJECTIVE.—: To review the clinicopathologic features of leiomyosarcoma of bone and present the most up-to-date understanding of its behavior and management in accordance with the current literature.
DATA SOURCES.—: Review of pertinent literature on the major features, current knowledge thereof, and the authors' experience in the diagnosis and management of leiomyosarcoma of bone.
CONCLUSIONS.—: Leiomyosarcoma of bone is a rare but well-recognized primary osseous sarcoma that may arise de novo or in association with radiation. Although it is diagnostically challenging, awareness of this rare sarcoma and knowledge of its key histomorphologic and immunohistochemical features allow for accurate diagnosis.
骨平滑肌肉瘤是一种罕见的原发性骨肉瘤，其特征为平滑肌分化和无恶性骨样组织形成。骨平滑肌肉瘤的诊断具有挑战性；通过提高对该实体的认识并能够将其与组织学模拟物区分开来，可以改善这种情况。由于其罕见性，文献中只有少数研究可用。这些因素导致我们对其病理学、预后和治疗的了解有限。
回顾骨平滑肌肉瘤的临床病理特征，并根据当前文献，介绍对其行为和管理的最新理解。
对骨平滑肌肉瘤的主要特征、当前知识以及作者在诊断和管理骨平滑肌肉瘤方面的经验进行的相关文献复习。
骨平滑肌肉瘤是一种罕见但已被充分认识的原发性骨肉瘤，可在没有辐射的情况下或在辐射后发生。尽管它的诊断具有挑战性，但对这种罕见肉瘤的认识和对其关键组织形态学和免疫组织化学特征的了解，有助于进行准确诊断。
