Korneev K V
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
Mol Biol (Mosk). 2019 Sep-Oct;53(5):799-814. doi: 10.1134/S0026898419050100.
An extensive network of regulation of systemic inflammation makes development of a reproducible experimental model of sepsis a complex task. There is no single mouse model that can capture all clinical aspects of this complicated pathology. However, a combination of existing approaches can go a long way towards analysis of specific mechanisms of sepsis development and to the design of novel therapeutic approaches. This review describes the popular mouse models of sepsis and septic shock, as well as their limitations and development strategies.
全身性炎症调节的广泛网络使得建立一个可重复的脓毒症实验模型成为一项复杂的任务。没有单一的小鼠模型能够涵盖这种复杂病理的所有临床方面。然而，现有方法的组合在分析脓毒症发展的特定机制以及设计新的治疗方法方面可以大有作为。这篇综述描述了脓毒症和脓毒性休克常见的小鼠模型，以及它们的局限性和发展策略。
