A Single Dose of The Mango Leaf Extract Zynamite in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women.

The mango leaf extract rich in mangiferin Zynamite improves exercise performance when combined with luteolin or quercetin ingested at least 48 h prior to exercise. To determine whether a single dose of Zynamite administered 1 h before exercise increases repeated-sprint performance, 20 men and 20 women who were physically active were randomly assigned to three treatments following a double-blind cross-over counterbalanced design. Treatment A, 140 mg of Zynamite, 140 mg of quercetin, 147.7 mg of maltodextrin, and 420 mg of sunflower lecithin; Treatment B, 140 mg of Zynamite, 140 mg of quercetin, and 2126 mg of maltodextrin and Treatment C, 2548 mg of maltodextrin (placebo). Subjects performed three Wingate tests interspaced by 4 min and a final 15 s sprint after ischemia. Treatments A and B improved peak power output during the first three Wingates by 2.8% and 3.8%, respectively (treatment x sprint interaction, = 0.01). Vastus Lateralis oxygenation (NIRS) was reduced, indicating higher O extraction (treatment × sprint interaction, = 0.01). Improved O extraction was observed in the sprints after ischemia ( = 0.008; placebo vs. mean of treatments A and B). Blood lactate concentration was 5.9% lower after the ingestion of Zynamite® with quercetin in men (treatment by sex interaction, = 0.049). There was a higher Vastus Lateralis O extraction during 60 s ischemia with polyphenols (treatment effect, = 0.03), due to the greater muscle VO in men ( = 0.001). In conclusion, a single dose of Zynamite combined with quercetin one hour before exercise improves repeated-sprint performance and muscle O extraction and mitochondrial O consumption during ischemia. No advantage was obtained from the addition of phospholipids.