Seppä L
Faculty of Dentistry, University of Kuopio, Finland.
Scand J Dent Res. 1988 Aug;96(4):304-9. doi: 10.1111/j.1600-0722.1988.tb01560.x.
To study the efficacy of sodium fluoride varnishes and a NaF solution in remineralization of enamel, 120 slabs of non-carious human enamel enamel were presoftened for 6 h and randomly divided into six groups. The slabs were stored in synthetic saliva for 9 days, except for a daily 30-min immersion in 0.1 M lactic acid-NaOH buffer. During the 9-day period, one group of the slabs received no treatment, and the rest were treated once or three times with 2.3% or 1.1% sodium fluoride varnish Duraphat, or nine times with a 0.1% NaF solution. Finally, the slabs were demineralized for 1 h, and the amount of dissolved Ca and F was determined. Microhardness of enamel was determined initially, after presoftening, after the 9-day period, and after the 1-h demineralization. All fluoride treatments prevented enamel softening almost completely during the 9 days, but the control slabs softened markedly. Fluoride varnishes were more effective than NaF solution. Three applications of 2.3% Duraphat were slightly more effective than any of the other varnish treatments, but one treatment with 2.3% varnish was not more effective than treatments with 1.1% varnish. Enamel treated three times with 1.1% varnish showed the greatest acid resistance during the 1-h demineralization. The results suggest that the efficacy of the varnish was not proportional to the fluoride concentration but rather to the number of applications. Fluoride uptake by enamel was greatest with the most concentrated varnish. Enamel solubility was not, however, directly proportional to the fluoride content of enamel.
为研究氟化钠 varnishes 和 NaF 溶液对牙釉质再矿化的效果，将 120 块无龋人类牙釉质板预软化 6 小时，随机分为六组。除每天在 0.1 M 乳酸 - 氢氧化钠缓冲液中浸泡 30 分钟外，这些板在合成唾液中储存 9 天。在这 9 天期间，一组板未接受任何处理，其余的则用 2.3%或 1.1%的氟化钠 varnish Duraphat 处理一次或三次，或用 0.1%的 NaF 溶液处理九次。最后，将这些板脱矿 1 小时，并测定溶解的钙和氟的量。在预软化后、9 天期间后以及 1 小时脱矿后，分别测定牙釉质的显微硬度。所有的氟化物处理在 9 天内几乎完全防止了牙釉质软化，但对照组的板明显软化。氟化钠 varnishes 比 NaF 溶液更有效。2.3%的 Duraphat 处理三次比其他任何 varnish 处理都稍有效，但 2.3%的 varnish 处理一次并不比 1.1%的 varnish 处理更有效。用 1.1%的 varnish 处理三次的牙釉质在 1 小时脱矿期间表现出最大的耐酸性。结果表明，varnish 的效果与氟化物浓度不成正比，而是与应用次数有关。牙釉质对最浓缩的 varnish 的氟摄取量最大。然而，牙釉质的溶解度与牙釉质中的氟含量并非直接成正比。
