子痫前期与产后代谢综合征风险的关联：一项荟萃分析。
The association between preeclampsia and the risk of metabolic syndrome after delivery: a meta-analysis.
机构信息
Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
J Matern Fetal Neonatal Med. 2021 Oct;34(19):3253-3258. doi: 10.1080/14767058.2019.1678138. Epub 2019 Oct 29.
OBJECTIVE
We performed a systematic review and meta-analysis to summarize the epidemiologic evidence of the association between preeclampsia and increased risk of metabolic syndrome after delivery.
METHODS
A comprehensive literature search of numerous electronic databases including PubMed, Scopus, and Web of Sciences was performed until 1 July 2019. The pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated as random effect estimates of association among studies. Begg's and Egger's linear regression tests were employed to investigate publication bias.
RESULTS
The pooled estimates of crude and adjusted ORs showed a significant association between preeclampsia and the risk of metabolic syndrome ((crude OR = 2.93, 95% CI = 1.92-4.47) and (adjusted OR = 1.62, 95% CI = 1.25-2.08)), respectively.
CONCLUSIONS
The results of this meta-analysis provide evidence for relation between preeclampsia and increase in risk of metabolic syndrome. However, more epidemiological and clinical studies are needed to explore the mechanism of preeclampsia on increased risk of metabolic syndrome.
目的
我们进行了系统评价和荟萃分析，以总结子痫前期与产后代谢综合征风险增加之间关联的流行病学证据。
方法
对包括 PubMed、Scopus 和 Web of Sciences 在内的多个电子数据库进行了全面的文献检索，检索截至 2019 年 7 月 1 日。采用随机效应模型汇总研究间的关联，计算合并的优势比（OR）及其 95％置信区间（CI）。采用 Begg 和 Egger 的线性回归检验来评估发表偏倚。
结果
未校正和校正的 OR 的合并估计值表明，子痫前期与代谢综合征的风险之间存在显著关联（（未校正 OR = 2.93，95％CI = 1.92-4.47）和（校正 OR = 1.62，95％CI = 1.25-2.08））。
结论
这项荟萃分析的结果为子痫前期与代谢综合征风险增加之间的关系提供了证据。但是，需要更多的流行病学和临床研究来探讨子痫前期增加代谢综合征风险的机制。
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