孕期农药和多氯联苯暴露与儿童自闭症谱系障碍之间的关联：一项荟萃分析。
Association between pesticide and polychlorinated biphenyl exposure during pregnancy and autism spectrum disorder among children: a meta-analysis.
作者信息
Mehri Fereshteh, Bashirian Saeid, Khazaei Salman, Jenabi Ensiyeh
机构信息
Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Clin Exp Pediatr. 2021 Jun;64(6):286-292. doi: 10.3345/cep.2020.00864. Epub 2020 Jul 27.
BACKGROUND
The effect of exposure to environmental factors on autism spectrum disorders (ASD), especially during pregnancy, is unclear.
PURPOSE
This meta-analysis investigated the association between exposure to pesticides and polychlorinated biphenyls (PCBs) during pregnancy and ASD risk among children.
METHODS
We searched Scopus, PubMed, Web of Science, and ProQuest for articles published through September 2019. Random-effects models were used to examine the association among studies using pooled odds ratios (ORs) and their 95% confidence intervals (CI). I2 tests were used to measure interstudy heterogeneity.
RESULTS
The pooled OR indicated a significant association between PCB and pesticide exposure during pregnancy and ASD risk among children (OR, 1.80; 95% CI, 1.26-2.34; and OR, 1.20; 95% CI, 1.02-1.39), respectively.
CONCLUSION
Findings of the present study indicate that exposure to pesticides and PCBs during pregnancy may affect the risk of ASD among children.
背景
环境因素暴露对自闭症谱系障碍（ASD）的影响尚不清楚，尤其是在孕期。
目的
本荟萃分析调查孕期接触农药和多氯联苯（PCBs）与儿童患ASD风险之间的关联。
方法
我们检索了Scopus、PubMed、科学网和ProQuest数据库，查找截至2019年9月发表的文章。采用随机效应模型，使用合并比值比（OR）及其95%置信区间（CI）来检验各研究之间的关联。I2检验用于衡量研究间的异质性。
结果
合并OR分别表明孕期接触PCBs和农药与儿童患ASD风险之间存在显著关联（OR为1.80；95%CI为1.26 - 2.34；OR为1.20；95%CI为1.02 - 1.39）。
结论
本研究结果表明，孕期接触农药和PCBs可能会影响儿童患ASD的风险。
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