Kullaa-Mikkonen A
Department of Oral Surgery, Faculty of Dentistry, University of Kuopio, Finland.
Scand J Dent Res. 1988 Aug;96(4):366-75. doi: 10.1111/j.1600-0722.1988.tb01569.x.
Clinical and genetic characteristics of histologically defined fissured tongue were examined in a familial study. Fifteen probands with fissured tongue and four probands with geographic tongue were selected from earlier studies. In addition, 12 probands with tongue fissuring, but without changes of papillary structure, were included. The total sample consisted of 31 families; the number of family members examined was 185 (93 men, 92 women), and the mean age of the subjects was 20 yr (range 1-78). Diagnosis of tongue form was emphasized, and this study describes an in vivo method of stereomicroscopy for examining the dorsum of the tongue. According to genetic analysis, fissured tongue with smooth-surfaced papillae was transmitted as a dominant characteristic with incomplete penetrance and was preceded by geographic tongue. The severity of fissured tongue changed with increasing age. Tongue fissuring with normal-appearing filiform papillae was not familial and was not associated with geographic tongue. Fissuring with normal papillary structure should be considered as variations of normal anatomy, whereas fissured tongue and geographic tongue are a clinical and etiological disease entity.
在一项家族研究中，对组织学定义的沟纹舌的临床和遗传特征进行了检查。从早期研究中选取了15名沟纹舌先证者和4名地图舌先证者。此外，还纳入了12名有舌裂但乳头结构无变化的先证者。总样本包括31个家庭；接受检查的家庭成员有185名（93名男性，92名女性），受试者的平均年龄为20岁（范围1 - 78岁）。强调了舌部形态的诊断，本研究描述了一种用于检查舌背的体视显微镜体内检查方法。根据遗传分析，具有光滑表面乳头的沟纹舌作为一种显性特征传递，具有不完全外显率，且之前有地图舌。沟纹舌的严重程度随年龄增长而变化。丝状乳头外观正常的舌裂不具有家族性，且与地图舌无关。具有正常乳头结构的舌裂应被视为正常解剖结构的变异，而沟纹舌和地图舌是一种临床和病因学上的疾病实体。
