曼诺辛通过利什曼原虫影响中央碳代谢。
Mannogen-ing Central Carbon Metabolism by Leishmania.
机构信息
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA.
出版信息
Trends Parasitol. 2019 Dec;35(12):947-949. doi: 10.1016/j.pt.2019.10.001. Epub 2019 Oct 26.
Abstract
Leishmania parasites synthesize mannogens, a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al. The crucial roles of mannogen in regulating central carbon metabolism and in vivo virulence suggest the potential of MTPs as promising drug targets.
摘要
利什曼原虫寄生虫通过 Sernee 等人新发现的一系列甘露糖基转移酶/磷酸酶（MTPs）的合成和降解之间的精细相互作用合成甘露聚糖，这是一种独特的储存碳水化合物。甘露聚糖在调节中心碳代谢和体内毒力方面的关键作用表明 MTP 作为有前途的药物靶点的潜力。
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