Laboratório de Análises Clínicas, Centro Universitário Saúde ABC/Faculdade de Medicina do ABC, Santo Andre, Brazil.
Universidade Paulista, Sao Paulo, Brazil.
J Clin Pathol. 2020 May;73(5):273-277. doi: 10.1136/jclinpath-2019-206161. Epub 2019 Oct 29.
The aim of this study was to evaluate the mismatch repair gene expression and their correlation with in patients with oral squamous cell carcinoma (SCC).
Total RNA was isolated from 28 biopsy samples. A control group was composed of 20 volunteers. Differential expression of , and genes was accessed by quantitative PCR.
There is increased expression of all the analysed genes when the patients were smokers and alcoholics. In addition, there is increased expression of when SCC was removed from the base of the tongue. There was a correlation between and and as well as between repair genes and expression levels. There is increased expression of the gene in patients with SCC, especially in the alcoholics.
There is a strong indication that gene was expressed along with the studied repair genes, evidencing the possibility that this system can be activated by the inflammatory pathway.
本研究旨在评估口腔鳞状细胞癌（SCC）患者错配修复基因的表达及其与 的相关性。
从 28 个活检样本中分离总 RNA。对照组由 20 名志愿者组成。通过定量 PCR 检测 、 和 基因的差异表达。
当患者为吸烟者和酗酒者时，所有分析基因的表达均增加。此外，当 SCC 从舌根部切除时， 的表达增加。 和 以及 和 之间存在相关性，修复基因 和 的表达水平之间也存在相关性。SCC 患者的 基因表达增加，尤其是在酗酒者中。
有强烈的迹象表明 基因与研究的修复基因一起表达，表明该系统可能通过炎症途径被激活。
