碘-131 清甲后 SPECT/CT 比全身扫描更能准确预测甲状腺乳头状癌的复发。
I-131 Postablation SPECT/CT Predicts Relapse of Papillary Thyroid Carcinoma more Accurately than Whole Body Scan.
机构信息
Department of Medical Physics, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Department of Nuclear Medicine, Army Share Fund Hospital (417 NIMTS), Athens Greece and Department of Nuclear Medicine, Henry Dunant Hospital Centre, Athens, Greece.
出版信息
In Vivo. 2019 Nov-Dec;33(6):2255-2263. doi: 10.21873/invivo.11731.
BACKGROUND/AIM: The aim of the study was to prospectively compare I-131 postablation Whole Body scan (WBS) and Single Photon Emission Computerized Tomography/Computerized Tomography (SPECT/CT) scan on thyroid cancer patients.
PATIENTS AND METHODS
Overall, 58 patients with papillary thyroid carcinoma were submitted to total thyroidectomy and I-131 remnant ablation. Post-ablation WBS and SPECT/CT scans performed on the same day were compared. Results of SPECT/CT were confirmed by neck and upper mediastinum ultrasound scan and on specific cases by a fully diagnostic CT scan, other tests and definitive histology acting as the gold standard. A total of 36/58 patients were followed-up for 5 years to detect relapse.
RESULTS
Mac Nemar Chi square and Fisher's exact tests disclosed statistically significant differences between WBS and SPECT/CT scan, concerning cervical lymphadenopathy detection (p=0.031) and relapse prediction by NM stage (p=0.033), respectively; SPECT/CT was more accurate in both comparisons.
CONCLUSION
In papillary thyroid carcinoma I-131 post-ablation SPECT/CT scan detects cervical lymphadenopathy and predicts relapse by NM stage more accurately than WBS.
背景/目的：本研究旨在前瞻性比较碘-131 清甲后全身扫描（WBS）和单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）在甲状腺癌患者中的应用。
患者和方法
共有 58 例乳头状甲状腺癌患者接受了全甲状腺切除术和碘-131 残余消融术。同日进行的清甲后 WBS 和 SPECT/CT 扫描结果进行了比较。SPECT/CT 结果通过颈部和上纵隔超声扫描证实，并在特定情况下通过全诊断 CT 扫描、其他检查和明确的组织学检查（作为金标准）证实。共有 36/58 例患者接受了 5 年的随访，以检测复发。
结果
Mac Nemar Chi 平方和 Fisher 精确检验显示，WBS 和 SPECT/CT 扫描在颈淋巴结病检测（p=0.031）和 NM 分期预测复发（p=0.033）方面存在统计学显著差异；在这两种比较中，SPECT/CT 都更准确。
结论
在碘-131 清甲后，SPECT/CT 扫描比 WBS 更能准确检测颈淋巴结病，并预测 NM 分期的复发。
Zotero 插件