Guo Fei Fei, Cui Jiu Wei
Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.
J Oncol. 2019 Sep 24;2019:2592419. doi: 10.1155/2019/2592419. eCollection 2019.
Earlier studies on elucidating the role of lymphocytes in tumor immunity predominantly focused on T cells. However, the role of B cells in tumor immunity has increasingly received better attention in recent studies. The B cells that infiltrate tumor tissues are called tumor-infiltrating B cells (TIBs). It is found that TIBs play a multifaceted dual role in regulating tumor immunity rather than just tumor inhibition or promotion. In this article, latest research advances focusing on the relationship between TIBs and tumor complexity are reviewed, and light is shed on some novel ideas for exploiting TIBs as a possible tumor biomarker and potential therapeutic target against tumors.
早期关于阐明淋巴细胞在肿瘤免疫中作用的研究主要集中在T细胞上。然而，B细胞在肿瘤免疫中的作用在最近的研究中越来越受到更多关注。浸润肿瘤组织的B细胞被称为肿瘤浸润性B细胞（TIBs）。研究发现，TIBs在调节肿瘤免疫中发挥着多方面的双重作用，而不仅仅是抑制或促进肿瘤。本文综述了聚焦于TIBs与肿瘤复杂性之间关系的最新研究进展，并提出了一些关于将TIBs开发为可能的肿瘤生物标志物和潜在肿瘤治疗靶点的新观点。
