Malakhova Alena V, Rudko Olga I, Sobolev Vladimir V, Tretiakov Artemii V, Naumova Elena A, Kokaeva Zarema G, Azimova Julia E, Klimov Eugene A
Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
I.I. Mechnikov Research Institute for Vaccines and Sera, Laboratory of molecular immunology, Moscow, Russia.
AIMS Genet. 2019 Aug 20;6(3):55-63. doi: 10.3934/genet.2019.3.55. eCollection 2019.
Panic disorder is a complex disease of unclear etiology but with an apparent genetic component. gene product is involved in many cell processes owing to its function-regulation of the level of a second messenger cAMP. gene polymorphism has been shown to be associated with some mental disorders including panic disorder.
The goal of our study was to evaluate the role of 3 SNPs in the gene in the development of panic disorder.
94 patients diagnosed with panic disorder according to the DSM-IV criteria were enrolled in the study. The population control group included 192 subjects. Genotyping was carried out by real-time PCR with TaqMan probes.
The investigated substitutions are not associated with panic disorder in general and in female/male cohorts (p > 0.05). The analysis of complex genotypes demonstrated two protective complex genotypes (rs1040716:A, T + rs10454453:A + rs502958:A and rs1040716:A, T + rs502958:A) associated with panic disorder in general regardless of the patient's gender (p < 0.05). These genotypes did not correlate with the patient's sex.
We found two complex protective genotypes associated with panic disorder. This can be due to the fact that predisposition to the disease are associated with other genes, while gene polymorphism reduces their effect.
惊恐障碍是一种病因不明的复杂疾病，但具有明显的遗传成分。[基因名称]基因产物由于其对第二信使环磷酸腺苷（cAMP）水平的功能调节而参与许多细胞过程。[基因名称]基因多态性已被证明与包括惊恐障碍在内的一些精神障碍有关。
我们研究的目的是评估[基因名称]基因中的3个单核苷酸多态性（SNP）在惊恐障碍发生中的作用。
根据《精神疾病诊断与统计手册》第四版（DSM-IV）标准诊断为惊恐障碍的94例患者纳入研究。人群对照组包括192名受试者。采用TaqMan探针实时荧光定量聚合酶链反应（PCR）进行基因分型。
所研究的替换位点总体上以及在女性/男性队列中均与惊恐障碍无关（p>0.05）。对复杂基因型的分析表明，有两种保护性复杂基因型（rs1040716：A，T+rs10454453：A+rs502958：A和rs1040716：A，T+rs502958：A）总体上与惊恐障碍相关，与患者性别无关（p<0.05）。这些基因型与患者性别无关。
我们发现了两种与惊恐障碍相关的复杂保护性基因型。这可能是由于该疾病的易感性与其他基因有关，而[基因名称]基因多态性降低了它们的作用。
