Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.
Org Lett. 2019 Nov 15;21(22):8962-8965. doi: 10.1021/acs.orglett.9b03347. Epub 2019 Oct 30.
A versatile thermal Overman rearrangement of enantioenriched, cyclic allylic alcohols providing tertiary allylic amines has been developed. The vinyl bromide used to control enantioselectivity in a preceding CBS reduction is utilized as a synthetic handle for the preparation of tertiary α-amino ketones and related derivatives in an asymmetric fashion.
一种通用的热 Overman 重排反应，可以将手性富集的环状烯丙醇转化为三级烯丙基胺，已经被开发出来。在之前的 CBS 还原中控制对映选择性的溴乙烯被用作合成手性制备三级α-氨基酮和相关衍生物的方法。
