Akram Muhammad, Daniyal Muhammad, Munir Naveed, Mohiuddin Ejaz, Sultana Sabira
Department of Eastern Medicine, Government College University Faisalabad, Faisalabad, Pakistan.
TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative MateriaMedica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
J Nerv Ment Dis. 2019 Nov;207(11):927-935. doi: 10.1097/NMD.0000000000001052.
Insomnia is a state defined as trouble with sleep; it is a chronically disabling condition and is now significantly prevalent, imposing enormous health and economic burdens both on individuals and on society. This state includes trouble in falling asleep, problems staying asleep, fragmented sleep (repeatedly awakening at night), and/or awakening before time in the morning. This difficulty in sleeping causes feeling exhausted during the day and trouble with daytime activities including driving, family responsibilities, and completion of valued daily routines. Different types of synthetic sedative drugs are used to handle nervous system changes, but repeated use of sedatives caused tolerance in the human body. After a while, people had to take a heavy dose of sedative to make them feel sleepy, which imposes extra toxic effects on vital organs of the body. Medicinal plants are gaining more and more attention as sedative agents because herbs contained different types of natural bioactive metabolites with not well reported side effects. In addition, medicinal plants have economic, high efficacy and are easy available. So in current review plants possessing sedative activities have been compiled with their constituents responsible to manage insomnia. Review of the literature indicated that medicinal plants from various systems of medicine have been reported to possess sedative activity. This review suggests that medicinal plants are efficacious for insomnia; further laboratory and clinical studies are required.
失眠是一种被定义为睡眠困难的状态；它是一种长期使人衰弱的病症，目前极为普遍，给个人和社会都带来了巨大的健康和经济负担。这种状态包括入睡困难、难以保持睡眠、睡眠碎片化（夜间反复醒来）和/或早醒。这种睡眠困难会导致白天感到疲惫，以及在包括驾驶、家庭责任和完成重要日常事务等白天活动中出现问题。不同类型的合成镇静药物被用于应对神经系统变化，但反复使用镇静剂会使人体产生耐受性。一段时间后，人们不得不服用大剂量的镇静剂才能感到困倦，这会对身体的重要器官产生额外的毒性作用。药用植物作为镇静剂越来越受到关注，因为草药含有不同类型的天然生物活性代谢物，且副作用报道较少。此外，药用植物经济实惠、疗效高且易于获取。因此，在当前的综述中，已收集了具有镇静活性的植物及其负责治疗失眠的成分。文献综述表明，来自各种医学体系的药用植物均被报道具有镇静活性。本综述表明，药用植物对失眠有效；还需要进一步的实验室和临床研究。
