Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad Iran.
Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Neuropharmacol. 2024;22(7):1205-1232. doi: 10.2174/1570159X21666230621143944.
Insomnia is repeated difficulty in falling asleep, maintaining sleep, or experiencing lowquality sleep, resulting in some form of daytime disturbance. Sleeping disorders cause daytime fatigue, mental confusion, and over-sensitivity due to insufficient recovery from a sound sleep. There are some drugs, such as benzodiazepines and anti-histaminic agents, which help to sleep induction and insomnia cure. However, the prolonged administration is unsuitable because of tolerance and dependence. Therefore, the researchers attempt to find new medicines with lesser adverse effects. Natural products have always been good sources for developing new therapeutics for managing diseases such as cancer, cardiovascular disease, diabetes, insomnia, and liver and renal problems. Ample research has justified the acceptable reason and relevance of the use of these herbs in the treatment of insomnia. It is worth noting that in this study, we looked into various Persian herbs in a clinical trial and to treat insomnia, such as, lettuce, and . According to research, herb extracts and fractions, particularly n-butanol fractions with non-polar agents, impact the benzodiazepine receptors and have hypnotic properties. Also, alkaloids, glycosides, flavonoids, saponins, and tannins in practically every plant are mentioned making them the popular natural compounds to help with sleep disorders and promote calmness.
失眠是指入睡困难、睡眠维持障碍或睡眠质量下降，导致日间功能障碍的一种睡眠障碍。睡眠障碍会导致白天疲劳、精神错乱和过度敏感，因为无法从深度睡眠中充分恢复。有一些药物，如苯二氮䓬类和抗组胺药，有助于诱导睡眠和治疗失眠。然而，由于耐受性和依赖性，长期使用并不合适。因此，研究人员试图寻找不良反应较小的新药。天然产物一直是开发癌症、心血管疾病、糖尿病、失眠和肝肾问题等疾病新疗法的良好来源。大量研究证明了使用这些草药治疗失眠的合理性和相关性。值得注意的是，在这项研究中，我们在临床试验中研究了各种波斯草药，例如生菜和缬草，以治疗失眠。研究表明，草药提取物和馏分，特别是具有非极性试剂的正丁醇馏分，会影响苯二氮䓬受体并具有催眠特性。此外，实际上每种植物中的生物碱、糖苷、类黄酮、皂苷和鞣质都被提及，使它们成为治疗睡眠障碍和促进镇静的常用天然化合物。
