State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, People's Republic of China.
College of Pharmacy, Nankai University, Tianjin, 300071, People's Republic of China.
Top Curr Chem (Cham). 2019 Oct 30;377(6):34. doi: 10.1007/s41061-019-0258-z.
Given the unique properties of metal-organic frameworks (MOFs) including adjustable porosity, high surface area, and easy modification, they have attracted great attention as excellent solid supports for the incorporation of biomolecules. The formed biomolecules-MOFs composites show promising prospects in various fields such as biocatalysis, drug delivery, and biosensing. This review focuses on the state-of-the-art of biomolecules-incorporation using MOFs. Moreover, the relationship between properties of MOFs and biomolecules-incorporation is also discussed and highlighted. We hope this work will inspire the innovation in this emerging field for highly efficient synthesis of biomolecules-MOFs composites with various properties and advanced applications.
鉴于金属有机骨架(MOFs)具有独特的性质,包括可调孔隙率、高比表面积和易于修饰,它们作为生物分子的优良固相载体引起了极大的关注。形成的生物分子-MOFs 复合材料在生物催化、药物输送和生物传感等各个领域具有广阔的应用前景。本综述重点介绍了利用 MOFs 进行生物分子掺入的最新进展。此外,还讨论和强调了 MOFs 的性质与生物分子掺入之间的关系。我们希望这项工作将激发这一新兴领域的创新,以高效合成具有各种性质和先进应用的生物分子-MOFs 复合材料。