Chen Yawei, Zheng Huijie, Cao Yiting, Yang Jiajia, Zhou Huiyun
College of Chemical and Pharmaceutical Engineering, Henan University of Science and Technology, Luoyang 471023, Henan, China.
Sheng Wu Gong Cheng Xue Bao. 2023 Mar 25;39(3):930-941. doi: 10.13345/j.cjb.220623.
As an excellent hosting matrices for enzyme immobilization, metal-organic framework (MOFs) provides superior physical and chemical protection for biocatalytic reactions. In recent years, the hierarchical porous metal-organic frameworks (HP-MOFs) have shown great potential in enzyme immobilization due to their flexible structural advantages. To date, a variety of HP-MOFs with intrinsic or defective porous have been developed for the immobilization of enzymes. The catalytic activity, stability and reusability of enzyme@HP-MOFs composites are significantly enhanced. This review systematically summarized the strategies for developing enzyme@HP-MOFs composites. In addition, the latest applications of enzyme@HP-MOFs composites in catalytic synthesis, biosensing and biomedicine were described. Moreover, the challenges and opportunities in this field were discussed and envisioned.
作为酶固定化的优良载体，金属有机框架（MOFs）为生物催化反应提供了卓越的物理和化学保护。近年来，分级多孔金属有机框架（HP-MOFs）因其灵活的结构优势在酶固定化方面展现出巨大潜力。迄今为止，已开发出多种具有固有或缺陷孔道的HP-MOFs用于酶的固定化。酶@HP-MOFs复合材料的催化活性、稳定性和可重复使用性显著提高。本综述系统总结了制备酶@HP-MOFs复合材料的策略。此外，还描述了酶@HP-MOFs复合材料在催化合成、生物传感和生物医学方面的最新应用。此外，还讨论并展望了该领域的挑战与机遇。
