Centre for Clinical Research in Infection and Sexual Health, UCL Institute for Global Health, University College London, London, UK.
Mortimer Market Centre, UCL Institute for Global Health, Off Capper Street, London, WC1E 6JB, UK.
AIDS Behav. 2020 Jun;24(6):1717-1726. doi: 10.1007/s10461-019-02714-2.
Alcohol misuse has been associated with negative consequences among HIV-positive patients. Data on real prevalence of risky alcohol consumption among the HIV-positive population in the UK are lacking. A cross-sectional questionnaire study using standardised validated instruments among HIV-positive (n = 227) and HIV-negative (n = 69) patients was performed. The prevalence of risky alcohol consumption (AUDIT) and associations with depressive symptoms (PHQ-9), problematic drug use (DUDIT), adherence to ART (CASE Adherence Index), sexual behaviour and demographic characteristics were assessed among both patient groups independently. A quarter (25.1%) of HIV-positive patients and 36.1% of HIV-negative patients reported risky alcohol consumption (AUDIT-score ≥ 8). In the multivariable analysis among HIV-positive patients depressive symptoms (p = 0.03) and problematic drug use (p = 0.007) were associated with risky alcohol consumption. Among HIV-negative patients these associations were not present. Risky alcohol consumption among HIV-positive patients is prevalent, and together with depressive symptoms and problematic drug use, may influence HIV-disease progression and patients' wellbeing.
酒精滥用与 HIV 阳性患者的负面后果有关。目前缺乏英国 HIV 阳性人群中危险饮酒实际流行率的数据。对 227 名 HIV 阳性患者和 69 名 HIV 阴性患者进行了横断面问卷调查研究，使用标准化的验证工具。在两个患者组中，分别评估了危险饮酒（AUDIT）的流行率以及与抑郁症状（PHQ-9）、药物使用问题（DUDIT）、ART 依从性（CASE 依从性指数）、性行为和人口统计学特征的相关性。四分之一（25.1%）的 HIV 阳性患者和 36.1%的 HIV 阴性患者报告了危险饮酒（AUDIT 评分≥8）。在 HIV 阳性患者的多变量分析中，抑郁症状（p=0.03）和药物使用问题（p=0.007）与危险饮酒有关。在 HIV 阴性患者中，这些相关性并不存在。HIV 阳性患者的危险饮酒很普遍，并且与抑郁症状和药物使用问题一起，可能会影响 HIV 疾病进展和患者的健康状况。
