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食管静脉曲张硬化剂注射。1964年至1977年间247例治疗病例分析(作者译)

[Sclerosing injections of oesophageal varices. Analysis of 247 cases treated between 1964 and 1977 (author's transl)].

作者信息

Pinel J, Gourod D, Trotoux J, Richard R, Netter J, Léger L

出版信息

Ann Otolaryngol Chir Cervicofac. 1979 Sep-Oct;96(10-11):685-97.

PMID:316664
Abstract

The authors analyse 247 cases of haemorrhagic oesophageal varices treated using sclerosing injections of Quinine-Urea between 1964 and 1977. Portal hypertension as a result of intrahepatic block accounted for 83% of the patients (alcoholic cirrhosis 65%, meta-icteric 12%) and cavernomas 11%. Sclerosing injections were used in patients refused by surgeons (85%) or after the failure of surgery (15%). Only 11 cases were treated during the period of active haemorrhage, and the others during the following weeks. Tolerance of treatment so long as all safety factors were employed routinely in order to deal with any possible haemorrhagic complications. Deaths due to the method totalled 2.8%, including those due to worsening of the underlying disease. Overall results were of 69% survival of more than one year, 40% at more than 3 years and 24% at more than five years. For alcoholic cirrhosis, these figures were respectively 62, 30 and 18%. The prognosis in cases of cavernoma was much better; 80% survival at more than 5 years.

摘要

作者分析了1964年至1977年间采用奎宁 - 尿素硬化注射治疗的247例出血性食管静脉曲张病例。肝内阻塞导致的门静脉高压占患者的83%(酒精性肝硬化65%,间质性黄疸12%),海绵状血管瘤占11%。硬化注射用于外科医生拒绝治疗的患者(85%)或手术失败后的患者(15%)。仅11例在活动性出血期间接受治疗,其他患者在随后几周接受治疗。只要常规采用所有安全因素以应对任何可能的出血并发症,治疗耐受性良好。该方法导致的死亡总计2.8%,包括因基础疾病恶化导致的死亡。总体结果是,一年以上生存率为69%,三年以上为40%,五年以上为24%。对于酒精性肝硬化,这些数字分别为62%、30%和18%。海绵状血管瘤病例的预后要好得多;五年以上生存率为80%。

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