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[食管静脉曲张硬化术。十年经验结果]

[Sclerosis of esophageal varices. Results of 10 years experience].

作者信息

Pinel J, Trotoux J, Richard R, Beutter P

出版信息

Ann Otolaryngol Chir Cervicofac. 1976 Apr-May;93(4-5):245-54.

PMID:952446
Abstract

Before they give their results, the authors, whose experience of sclerosis of oesophageal varices under the oesophagoscope has so far involved 157 patients, deal specifically with the problems facing the anaesthetist and resuscitator when this technique is used, tolerance of the product injected and possible accidents. Firstly, they point out the unsuitability of the patients referred to them by their medical or surgical colleagues. By implication therefore, treatment should only be undertaken with the assistance of a team of experienced resuscitators and every precaution taken to mitigate the effects of possible accidents to these patients who are particularly at risk. These cases are mainly characterized by serious haemorrhages (seven cases described, one resulting in death). Oesophageal injury is, on the other hand, the exception where trained personnel are involved (2 minor mucosal tears out of more than 800 oesophagoscopies). Finally, secondary parietal oesophageal necrosis occurs. Quininaemia assessment after injection of quinine-urea confirms that the product is being efficiently eliminated. Overall results reveal a survival rate of 61 p. 100 after more than a year and 20 p. 100 after more than than three years. These figures underline the limitations of therapeutic possibilities and the serious prognosis for this result of portal hypertension. This leads the authors to express a wish that the procedure should be used as a measure to prevent haemorrhage as soon as the presence of varices is realized. On the other hand, they reject on practical grounds emergency sclerosis of oesophageal varices, as a direct heamostatic method, since, according to their statistics, this almost invariably results in failure.

摘要

在公布结果之前,这些作者(他们通过食管镜治疗食管静脉曲张的经验目前已涉及157例患者)专门讨论了使用该技术时麻醉师和复苏人员面临的问题、所注射产品的耐受性以及可能发生的意外情况。首先,他们指出医学或外科同事转介给他们的患者并不合适。因此,这意味着治疗应仅在经验丰富的复苏团队的协助下进行,并采取一切预防措施来减轻这些特别高危患者可能发生的意外情况的影响。这些病例主要以严重出血为特征(描述了7例,其中1例导致死亡)。另一方面,在有训练有素的人员参与的情况下,食管损伤是例外情况(在800多次食管镜检查中出现2例轻微黏膜撕裂)。最后,发生了继发性食管壁坏死。注射奎宁 - 尿素后对奎宁血症的评估证实该产品正在被有效清除。总体结果显示,一年多后的生存率为61%,三年多后的生存率为20%。这些数字突显了治疗可能性的局限性以及门静脉高压症这种结果的严重预后。这使得作者们希望一旦意识到静脉曲张的存在,就应将该手术用作预防出血的措施。另一方面,他们基于实际理由拒绝将食管静脉曲张紧急硬化术作为一种直接的止血方法,因为根据他们的统计,这几乎总是导致失败。

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