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一种与显微镜下多血管炎相关的严重胸膜并发症。

A severe pleural complication associated with granulomatosis with polyangiitis.

作者信息

Chin Melanie, Leblanc Aaron, Souza Carolina, Gomes Marcio M, Ivory Catherine, Midzic Ines, Mulpuru Sunita

机构信息

Division of Respirology, Department of Medicine, University of Ottawa, Canada.

The Ottawa Hospital, Ottawa, Canada.

出版信息

Respir Med Case Rep. 2019 Sep 15;28:100933. doi: 10.1016/j.rmcr.2019.100933. eCollection 2019.

DOI:10.1016/j.rmcr.2019.100933
PMID:31667069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6812348/
Abstract

We describe the case of a previously healthy male patient who presented to a respiratory clinic with sinusitis, pulmonary cavities, and hemoptysis. Three weeks following a diagnosis of Granulomatosis with Polyangiitis (GPA) and initiation of immunosuppressive treatment, the patient suddenly developed a large pneumothorax that was complicated by empyema. In this report we discuss and highlight the rare pleural complications associated with GPA, and alert clinicians to monitor for these important complications even after disease-modifying treatment is initiated.

摘要

我们描述了一名既往健康的男性患者的病例,该患者因鼻窦炎、肺空洞和咯血就诊于呼吸科诊所。在诊断为肉芽肿性多血管炎(GPA)并开始免疫抑制治疗三周后,患者突然出现大量气胸,并并发脓胸。在本报告中,我们讨论并强调了与GPA相关的罕见胸膜并发症,并提醒临床医生即使在开始疾病改善治疗后也要监测这些重要并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/6bc737787d16/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/ff5a9feb3215/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/595e20f4edbb/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/dc876ccbac53/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/795889b922ef/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/6bc737787d16/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/ff5a9feb3215/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/595e20f4edbb/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/dc876ccbac53/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/795889b922ef/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4797/6812348/6bc737787d16/gr5.jpg

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本文引用的文献

1
Risk factors and treatment of pneumothorax secondary to granulomatosis with polyangiitis: a clinical analysis of 25 cases.肉芽肿性多血管炎继发气胸的危险因素及治疗:25例临床分析
J Cardiothorac Surg. 2018 Jan 15;13(1):7. doi: 10.1186/s13019-018-0695-8.
2
Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener's granulomatosis).肉芽肿性多血管炎(又名韦格纳氏肉芽肿病)的诊断和分类。
J Autoimmun. 2014 Feb-Mar;48-49:94-8. doi: 10.1016/j.jaut.2014.01.028. Epub 2014 Jan 29.
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Spontaneous pneumothorax in a patient with granulomatosis with polyangiitis.
患有肉芽肿性多血管炎的患者发生自发性气胸。
BMJ Case Rep. 2012 Nov 30;2012:bcr2012007765. doi: 10.1136/bcr-2012-007765.
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Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation.胸部 CT 常见和不常见的 Wegener 肉芽肿表现:影像学-病理学相关性。
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Nomenclature and classification of vasculitis: lessons learned from granulomatosis with polyangiitis (Wegener's granulomatosis).血管炎的命名和分类:从肉芽肿性多血管炎(韦格纳肉芽肿病)中吸取的经验教训。
Clin Exp Immunol. 2011 May;164 Suppl 1(Suppl 1):7-10. doi: 10.1111/j.1365-2249.2011.04357.x.
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Mod Rheumatol. 2008;18(1):76-80. doi: 10.1007/s10165-007-0007-y. Epub 2007 Dec 27.
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ANCA are detectable in nearly all patients with active severe Wegener's granulomatosis.在几乎所有活动性重症韦格纳肉芽肿患者中均可检测到抗中性粒细胞胞浆抗体。
Am J Med. 2007 Jul;120(7):643.e9-14. doi: 10.1016/j.amjmed.2006.08.016.
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Unusual pathogenesis of spontaneous pneumothorax secondary to Wegener's granulomatosis.
Ann Thorac Surg. 2007 Jul;84(1):288-90. doi: 10.1016/j.athoracsur.2007.01.038.
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Spontaneous pneumothorax in Wegener granulomatosis.韦格纳肉芽肿病中的自发性气胸。
Chest. 2005 Oct;128(4):3074-5. doi: 10.1378/chest.128.4.3074.