Zheng Xiaomei, Zheng Ping, Sun Jibin
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Sheng Wu Gong Cheng Xue Bao. 2019 Oct 25;35(10):1955-1973. doi: 10.13345/j.cjb.190217.
In industrial biotechnology, microbial cell factories utilize renewable resources to produce energy, materials and chemicals. Industrial biotechnology plays an increasingly important role in solving the resource, energy and environmental problems. Systems biology has shed new light on industrial biotechnology, deepening our understanding of industrial microbial cell factories and their bioprocess from "Black-box" to "White-box". Systems-wide profiling of genome, transcriptome, proteome, metabolome, and fluxome has proven valuable to better unveil network operation and regulation on the genome scale. System biology has been successfully applied to create microbial cell factories for numerous products and derive attractive industrial processes, which has constantly expedited the development of industrial biotechnology. This review focused on the recent advance and applications of omics and trans-omics in industrial biotechnology, including genomics, transcriptomics, proteomics, metabolomics, fluxomics and genome scale modeling, and so on. Furthermore, this review also discussed the potential and promise of systems biology in industrial biotechnology.
在工业生物技术中，微生物细胞工厂利用可再生资源生产能源、材料和化学品。工业生物技术在解决资源、能源和环境问题方面发挥着越来越重要的作用。系统生物学为工业生物技术带来了新的启示，加深了我们对工业微生物细胞工厂及其生物过程从“黑箱”到“白箱”的理解。对基因组、转录组、蛋白质组、代谢组和通量组进行全系统分析已被证明有助于在基因组规模上更好地揭示网络运作和调控机制。系统生物学已成功应用于创建用于多种产品的微生物细胞工厂，并衍生出具有吸引力的工业流程，这不断推动着工业生物技术的发展。本综述重点关注组学和跨组学在工业生物技术中的最新进展与应用，包括基因组学、转录组学、蛋白质组学、代谢组学、通量组学和基因组规模建模等。此外，本综述还讨论了系统生物学在工业生物技术中的潜力和前景。
