Li Demao, Chen Wuxi, Guo Wei, Li Chaofeng
Tianjin Key Laboratory for Industrial Biosystems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Sheng Wu Gong Cheng Xue Bao. 2019 Oct 25;35(10):1974-1985. doi: 10.13345/j.cjb.190249.
Industrial fermentation is the basic operation unit of industrial biotechnology in large-scale production. Mathematical simulation of microbial cells and their reactors will help deepen the understanding of microorganisms and fermentation processes, and will also provide solutions for the construction of new synthetic organisms. In this paper, the characteristics of industrial fermentation system, the development of mathematical simulation, the classification, characteristics and functions of mathematical models are described in depth, and the development trend of whole fermentation system simulation is prospected.
工业发酵是工业生物技术大规模生产中的基本操作单元。微生物细胞及其反应器的数学模拟将有助于加深对微生物和发酵过程的理解，也将为新型合成生物的构建提供解决方案。本文深入阐述了工业发酵系统的特点、数学模拟的发展、数学模型的分类、特点及作用，并展望了全发酵系统模拟的发展趋势。
