Department of Neurology, Dokkyo Medical University, Tochigi, Japan; Center of Sleep Medicine, Dokkyo Medical University Hospital, Tochigi, Japan.
Department of Neurology, Dokkyo Medical University, Tochigi, Japan.
J Neurol Sci. 2019 Dec 15;407:116519. doi: 10.1016/j.jns.2019.116519. Epub 2019 Oct 20.
Restless legs syndrome (RLS) is characterized by the urge to move the legs accompanied by movement-responsive, abnormal sensations, which worsen at rest and night. We investigated the distribution of sensory symptoms and clinical correlations in patients with RLS and its variants.
Eighty-nine patients diagnosed with RLS or RLS variants (age 61.4 ± 18.5 years 40 M/49 F) according to established criteria, with the exclusion of those with augmentation, were included in this study. The international RLS rating scale (IRLS) was used to assess the severity of RLS/RLS variant symptoms.
Eighty-three patients (93.3%) had RLS, and 6 patients (6.7%) had RLS variants. Among the patients with RLS and RLS variants, 33 patients (36.0%) reported restlessness involving other body parts: arms (16.9%) were the most frequent region, followed by the back (10.1%), abdomen (6.7%), and buttocks (4.5%). There were no between-group differences in clinical characteristics, except for the level of sleep disturbances being higher in patients with RLS variants (n=6) than in patients with RLS (n=83). No significant difference was observed in clinical characteristics including RLS severity and treatment between patients with RLS only (n=57) and patients with RLS with other body part involvement (n=26). No relationship was observed between the onset of symptoms in the legs and other body parts, but the IRLS scores for legs and other body parts were significantly correlated.
We should recognize that RLS can involve not only legs but also other body parts to varying degrees in each patient.
不宁腿综合征（RLS）的特征是腿部有强烈的活动欲望，同时伴有运动反应性异常感觉，这些症状在休息和夜间时会加重。我们研究了 RLS 及其变异型患者的感觉症状分布和临床相关性。
根据既定标准，排除增龄现象后，本研究纳入了 89 例被诊断为 RLS 或 RLS 变异型（年龄 61.4±18.5 岁，40 男/49 女）的患者。使用国际 RLS 评分量表（IRLS）评估 RLS/RLS 变异型症状的严重程度。
83 例患者（93.3%）患有 RLS，6 例患者（6.7%）患有 RLS 变异型。在 RLS 和 RLS 变异型患者中，有 33 例（36.0%）报告腿部以外的其他部位有不适感：手臂（16.9%）是最常见的部位，其次是背部（10.1%）、腹部（6.7%）和臀部（4.5%）。除 RLS 变异型（n=6）患者的睡眠障碍程度高于 RLS 患者（n=83）外，两组患者的临床特征无差异。仅 RLS 患者（n=57）和 RLS 伴有其他部位受累患者（n=26）的 RLS 严重程度和治疗无显著差异。腿部和其他部位症状的发病时间无显著相关性，但 IRLS 腿部和其他部位评分显著相关。
我们应该认识到，RLS 可能会不同程度地累及每个患者的腿部和其他身体部位。
