Zulfiqar Abrar-Ahmad, Andres Emmanuel, Lorenzo Villalba Noel
Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, France.
Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, France. E-mail:
Medicina (B Aires). 2019;79(5):391-396.
High serum levels of vitamin B12 or cobalamin, also called hypervitaminemia B12, is a frequently underestimated biological abnormality. According to the literature, some of the entities related to this finding are solid neoplasia (primary or metastatic) and acute or chronic hematological diseases. Other causes include liver disorders, monoclonal gammapathy of undetermined significance, renal failure and, less frequently, excess of vitamin B12 intake, inflammatory or autoimmune diseases, and transient hematological disorders (neutrophilia and secondary eosinophilia). This article reports on causes of hypervitaminosis B12, our experience and a review of the literature.
血清维生素B12或钴胺素水平过高,也称为维生素B12血症,是一种经常被低估的生物学异常情况。根据文献记载,与这一发现相关的一些情况包括实体瘤(原发性或转移性)以及急性或慢性血液系统疾病。其他原因包括肝脏疾病、意义未明的单克隆丙种球蛋白病、肾衰竭,较少见的原因还有维生素B12摄入过量、炎症或自身免疫性疾病以及短暂性血液系统疾病(中性粒细胞增多症和继发性嗜酸性粒细胞增多症)。本文报告了维生素B12过多症的病因、我们的经验以及文献综述。