麦地那国王萨勒曼医疗城（KSAMC）就诊患者中血清维生素B12水平高的合并症疾病发生率

Frequency of comorbid diseases with high serum Vitamin B12 levels in patients attending King Salman Medical City (KSAMC), at Madinah.

作者信息

Abu-Zahab Zakia A, Qureshi Hina, Adham Gihan M, Elzefzafy Wafaa M, Zalam Sahar S, Rehan Abeer M, Abdelhameed Manal F, Bayoumy Amany A, AlKarkosh Sinna K, Fakhouri Waad G, Sharfi Ahmed Y, Alkhawaga Salwa A, El-Attar Lamaa M, Amin Sahar S, Alrefaei Ranin A

机构信息

Department of Clinical and Chemical Pathology -Faculty of Medicine for Girls Al-Azhar University, Cairo, Egypt.

Department of Laboratory, Madinah General Hospital, King Salman bin Abdul Aziz Medical City, Madinah Munnawarah, Saudi Arabia.

出版信息

Int J Health Sci (Qassim). 2025 Jan-Feb;19(1):15-21.

PMID:39760052

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11699236/

Abstract

OBJECTIVES

Vitamin B12 (Cobalamin or Cbl) plays a crucial role in normal human growth and development, as well as in neurological, cardiovascular, and immune systems. Previous studies reported association of high levels of cobalamin with solid cancers, hematological disorders, and liver diseases. Reporting the frequency of comorbid diseases with high serum Vitamin B12 level in patients attending KSAMC at Madinah.

METHODS

This is a retrospective, cross-sectional study on data collected during 1 year (May 2022-May 2023) from 3511 report, patients with high cobalamin blood level (normal upper limit 771 pg/mL) as determined in our laboratory on COBAS were included. Patient's clinical diagnosis, medication history and other laboratory parameters performed were also checked for disease comorbidities.

RESULTS

Our results revealed statistically significant increase in serum Vitamin B12 in patients with diabetes mellitus, with the use of this vitamin as supplement therapy 53.2% (the predominant comorbidity), together with liver, blood, chest, kidney, thyroid and neurological diseases, and various solid tumors. A positive correlation was found between serum Vitamin B12, age and laboratory parameters including aspartate aminotransferase, gamma-glutamyl transferase, and direct bilirubin, and a negative correlation was seen between serum Vitamin B12 level, serum albumin (ALB), red blood cell count, hemoglobin, and free T3 (FT3). While, no significant correlation with the rest of the checked parameters was detected.

CONCLUSION

This study found high serum level of Vitamin B12 associated with various disease entities, for example, (diabetes mellitus treated with Vitamin B12 as supplement therapy, liver, blood, chest, kidney, thyroid, neurological diseases, and various solid tumors), so when Vitamin B12 is high, further investigations will be recommended. Most of the comorbidities were benign in Saudis, followed by Egyptians with predominance of female-aged 50-70 year old.

摘要

目的

维生素B12（钴胺素或Cbl）在人类正常生长发育以及神经、心血管和免疫系统中发挥着关键作用。此前的研究报告了高钴胺素水平与实体癌、血液系统疾病和肝脏疾病之间的关联。报告麦地那国王沙特阿拉伯军事城（KSAMC）就诊患者中血清维生素B12水平高的合并疾病发生频率。

方法

这是一项回顾性横断面研究，对2022年5月至2023年5月这1年期间收集的3511份报告数据进行分析，纳入了经我们实验室在COBAS上测定的钴胺素血水平高（正常上限771 pg/mL）的患者。还检查了患者的临床诊断、用药史以及所进行的其他实验室参数以了解疾病合并症情况。

结果

我们的结果显示，糖尿病患者的血清维生素B12有统计学显著升高，使用这种维生素作为补充治疗的患者占53.2%（主要合并症），同时还有肝脏、血液、胸部、肾脏、甲状腺和神经系统疾病以及各种实体瘤。血清维生素B12与年龄以及包括天冬氨酸转氨酶、γ-谷氨酰转移酶和直接胆红素在内的实验室参数之间存在正相关，而血清维生素B12水平与血清白蛋白（ALB）、红细胞计数、血红蛋白和游离T3（FT3）之间存在负相关。同时，未检测到与其他检查参数有显著相关性。