Sharma R P, Pandey G N, Janicak P G, Peterson J, Comaty J E, Davis J M
Illinois State Psychiatric Institute, Chicago 60612.
Biol Psychiatry. 1988 Sep;24(5):555-68. doi: 10.1016/0006-3223(88)90166-7.
The authors present new data on the results of the pretreatment Dexamethasone Suppression Test (DST) in 164 drug-free inpatients, as well as on the effects of age on postdexamethasone cortisol values. Nonsuppression rates were 18% in schizophrenic patients (n = 44), versus 46% in patients with a major depression (n = 56). In addition, a significant correlation was found between age and the 4:00 PM postdexamethasone cortisol value among the depressed patients (r = 0.33). The authors then applied a metaanalysis to summarize 25 other studies that have addressed the schizophrenia/major depression dichotomy as it relates to the DST outcome. Nonsuppression rates were consistently different in schizophrenic patients (19%) when compared to patients with a major depression (51%) or normal controls (7%). These differences were highly significant as measured by the Mantel-Haenszel chi-square statistic. A metaanalysis applied to a series of correlations obtained from 14 other studies reporting an age/postdexamethasone cortisol relationship in affective patients indicated a modest, but significant correlation (r = 0.24) in a total of 1284 patients (p less than 1 x 10(-8)).
作者展示了164名未使用药物的住院患者预处理地塞米松抑制试验（DST）结果的新数据，以及年龄对服用地塞米松后皮质醇值的影响。精神分裂症患者（n = 44）的不抑制率为18%，而重度抑郁症患者（n = 56）的不抑制率为46%。此外，在抑郁症患者中，年龄与下午4点服用地塞米松后的皮质醇值之间存在显著相关性（r = 0.33）。作者随后进行了一项荟萃分析，以总结其他25项研究，这些研究探讨了精神分裂症/重度抑郁症二分法与DST结果的关系。与重度抑郁症患者（51%）或正常对照组（7%）相比，精神分裂症患者的不抑制率始终不同（19%）。通过Mantel-Haenszel卡方统计量测量，这些差异非常显著。对从其他14项研究中获得的一系列相关性进行的荟萃分析表明，在总共1284名情感障碍患者中存在适度但显著的相关性（r = 0.24）（p小于1×10^(-8)）。
