State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
International Center for Interdisciplinary Studies of Immunology (ICISI), Georgetown University Medical Center, Washington, DC 20057, United States.
Cytokine Growth Factor Rev. 2019 Oct;49:32-41. doi: 10.1016/j.cytogfr.2019.10.003. Epub 2019 Oct 18.
Allergic diseases are ubiquitous diseases with detrimental effects on the quality of life of people worldwide. Common allergic diseases include asthma, allergic rhinitis (AR) and allergic dermatitis (AD). Recently, studies have shown that interleukin (IL)-37, a novel cytokine in the IL-1 family, exhibits broad protective properties in various diseases, such as autoimmune diseases and cancer. IL-37 displays its anti-inflammatory effect on diseases by curbing innate and acquired immunity as well as inflammatory reactions. IL-37 functions by forming a complex with IL-18Rα and IL-1R8 extracellularly and can be translocated to the nucleus upon forming a complex with mothers against decapentaplegic homolog 3 (Smad3) intracellularly, thereby affecting gene transcription and signaling pathway activation. In addition, increasing evidence confirms that IL-37 expression is aberrant in asthma, AR and AD, which indicates that IL-37 may also play essential roles in allergic diseases. Furthermore, accumulating data obtained from recombinant IL-37 (rIL-37)-treated mice and from IL-37 transgenic (IL-37tg) mice suggest a protective role for IL-37. This review will detail the role of IL-37 in the occurrence and development of allergic diseases and discuss the potential of IL-37 as a therapeutic target in allergic diseases.
变应性疾病是全球性疾病，对人们的生活质量有不利影响。常见的变应性疾病包括哮喘、过敏性鼻炎（AR）和过敏性皮炎（AD）。最近的研究表明，白细胞介素（IL）-37是 IL-1 家族中的一种新型细胞因子，在各种疾病中具有广泛的保护作用，如自身免疫性疾病和癌症。IL-37 通过抑制先天和获得性免疫以及炎症反应来发挥其对疾病的抗炎作用。IL-37 通过与 IL-18Rα 和 IL-1R8 形成复合物在细胞外发挥作用，并可在与母亲抗 decapentaplegic 同源物 3（Smad3）形成复合物后被转运到细胞核内，从而影响基因转录和信号通路的激活。此外，越来越多的证据证实，IL-37 在哮喘、AR 和 AD 中的表达异常，这表明 IL-37 也可能在过敏性疾病中发挥重要作用。此外，来自重组 IL-37（rIL-37）治疗的小鼠和 IL-37 转基因（IL-37tg）小鼠的数据表明，IL-37 具有保护作用。本综述将详细阐述 IL-37 在变应性疾病发生和发展中的作用，并探讨 IL-37 作为变应性疾病治疗靶点的潜力。
