Fluen Thomas, Hardcastle Michael, Smith Helen L, Gear Robyn N A
Internal Medicine, Veterinary Internal Medicine Specialists, Auckland, New Zealand.
Anatomical Pathology, Gribbles Veterinary Pathology New Zealand, Auckland, New Zealand.
Vet Rec Open. 2019 Oct 3;6(1):e000367. doi: 10.1136/vetreco-2019-000367. eCollection 2019.
To retrospectively determine the relative frequency of feline hepatobiliary diseases from biopsy specimens submitted to a single laboratory across a 10-year period and to establish whether age, sex or breed associations exist.
Histopathological data from 154 liver biopsies of New Zealand cats sampled between 2008 and 2018 were analysed. The samples were allocated to primary, secondary and tertiary disease categories using criteria established by the World Small Animal Veterinary Association. Breed associations were derived using ORs and 95% CIs. Gender and age associations were also evaluated.
The most frequently diagnosed hepatobiliary diseases were lymphocytic cholangitis (20 per cent), hepatitis (16.9 per cent), reversible hepatocellular injury (16.4 per cent), neutrophilic cholangitis (9.7 per cent), haematopoietic neoplasia (9.7 per cent), hepatocellular neoplasia (5.6 per cent) and cholangiocellular neoplasia (4.1 per cent). Burmese cats were found to be at significantly increased risk of both biliary and parenchymal diseases and Birman cats to be at significantly increased risk of parenchymal disease. Domestic longhair cats were at significantly increased risk of hepatobiliary neoplasia. Birman cats were at significantly increased risk of hepatitis while domestic shorthair cats were at significantly decreased risk of neutrophilic cholangitis, reversible hepatocellular injury and hepatitis.
This study is the first retrospective examination of the relative frequency of hepatobiliary disease in biopsy specimens from New Zealand cats. Some breeds were associated with specific histopathology.
回顾性确定在10年期间提交至单个实验室的猫活检标本中猫肝胆疾病的相对频率，并确定是否存在年龄、性别或品种关联。
分析了2008年至2018年间采集的154只新西兰猫肝脏活检的组织病理学数据。使用世界小动物兽医协会制定的标准将样本分为原发性、继发性和三级疾病类别。通过比值比（OR）和95%可信区间（CI）得出品种关联。还评估了性别和年龄关联。
最常诊断出的肝胆疾病为淋巴细胞性胆管炎（20%）、肝炎（16.9%）、可逆性肝细胞损伤（16.4%）、嗜中性粒细胞性胆管炎（9.7%）、造血系统肿瘤（9.7%）、肝细胞肿瘤（5.6%）和胆管细胞肿瘤（4.1%）。发现缅甸猫患胆管和实质疾病的风险显著增加，伯曼猫患实质疾病的风险显著增加。家养长毛猫患肝胆肿瘤的风险显著增加。伯曼猫患肝炎的风险显著增加，而家养短毛猫患嗜中性粒细胞性胆管炎、可逆性肝细胞损伤和肝炎的风险显著降低。
本研究是首次对新西兰猫活检标本中肝胆疾病相对频率的回顾性研究。一些品种与特定的组织病理学相关。
