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Recent research trends and updates on nonalcoholic fatty liver disease.非酒精性脂肪性肝病的最新研究趋势和进展。
Clin Mol Hepatol. 2019 Mar;25(1):1-11. doi: 10.3350/cmh.2018.0037. Epub 2018 Aug 8.
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Nat Med. 2018 Jul;24(7):908-922. doi: 10.1038/s41591-018-0104-9. Epub 2018 Jul 2.
5
A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.一项关于西尼利尤单抗治疗伴有纤维化的非酒精性脂肪性肝炎的随机、安慰剂对照试验。
Hepatology. 2018 May;67(5):1754-1767. doi: 10.1002/hep.29477. Epub 2018 Jan 29.
6
Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD.纤维化分期而非 NASH 可预测经活检证实的非酒精性脂肪性肝病患者的死亡率和严重肝脏疾病的发生时间。
J Hepatol. 2017 Dec;67(6):1265-1273. doi: 10.1016/j.jhep.2017.07.027. Epub 2017 Aug 10.
7
Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.依洛前列素，一种过氧化物酶体增殖物激活受体-α和-δ激动剂，可在不加重肝纤维化的情况下诱导非酒精性脂肪性肝炎消退。
Gastroenterology. 2016 May;150(5):1147-1159.e5. doi: 10.1053/j.gastro.2016.01.038. Epub 2016 Feb 11.
8
Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study.基于前瞻性双胞胎研究的肝纤维化和脂肪变性的遗传性。
Gastroenterology. 2015 Dec;149(7):1784-93. doi: 10.1053/j.gastro.2015.08.011. Epub 2015 Aug 20.
9
Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease.肝纤维化而非其他组织学特征与非酒精性脂肪性肝病患者的长期预后相关。
Gastroenterology. 2015 Aug;149(2):389-97.e10. doi: 10.1053/j.gastro.2015.04.043. Epub 2015 Apr 29.
10
Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up.纤维化分期是经过长达 33 年随访后，NAFLD 患者疾病特异性死亡率的最强预测因子。
Hepatology. 2015 May;61(5):1547-54. doi: 10.1002/hep.27368. Epub 2015 Mar 23.

Overview of emerging treatment of non-alcoholic fatty liver disease: more than one drug needed?

作者信息

Kim Dong Yun, Park Jun Yong

机构信息

Department of Pharmacology, Yonsei University Graduate School of Medicine, Seoul, South Korea.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

出版信息

Hepatobiliary Surg Nutr. 2019 Oct;8(5):522-524. doi: 10.21037/hbsn.2019.05.08.

DOI:10.21037/hbsn.2019.05.08
PMID:31673545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6791976/
Abstract
摘要