Experimental Neuropathology Unit, Institut Pasteur, 28 rue Dr. Roux, 75015, Paris, France.
Innate Immun. 2020 Apr;26(3):165-171. doi: 10.1177/1753425919842307. Epub 2019 Nov 1.
André Boivin (1895–1949) started his career in Marseille as a biochemist. Soon after the discovery of insulin, he worked on its purification, allowing for the treatment of local patients. He later moved to Strasbourg and set-up a microtitration technique of small carbon molecules and a method for quantifying purine and pyrimidine bases. His main scientific contribution occurred in Bucharest, where he was recruited to organize the teaching of medicinal chemistry. Together with Ion and Lydia Mesrobeanu, at the Cantacuzene Institute, they were the first to characterize the biochemical nature of endotoxins, which he termed the “glucido-lipidic antigen.” After joining the Institut Pasteur annex near Paris, he worked with Gaston Ramon pursuing his research on smooth and rough LPS. Additionally, with Albert Delaunay, he researched the formation of exotoxins and antibodies (Abs). He was nominated assistant-director of the Institut Pasteur in 1940. He initiated research on bacterial DNA and RNA, and was the first to hypothesize on how RNA fits into gene function. In 1947 he moved for a second time to Strasbourg, accepting a position as a Professor of Biological Chemistry. After his premature death at the age of 54, the French academies mourned his loss and recognized him as one of their outstanding masters of biochemistry, microbiology, immunology, and molecular biology.
安德烈·博伊文（1895-1949 年）在马赛开始了他的职业生涯，是一名生化学家。在胰岛素被发现后不久，他就致力于其纯化工作，从而能够为当地患者进行治疗。之后，他搬到斯特拉斯堡，建立了一种小碳分子的微量滴定技术和嘌呤及嘧啶碱基定量方法。他的主要科学贡献发生在布加勒斯特，他在那里被招募来组织药物化学的教学。他与 Ion 和 Lydia Mesrobeanu 一起在 Cantacuzene 研究所，首次对内毒素的生化性质进行了特征描述，他将其命名为“糖脂抗原”。加入巴黎附近的巴斯德研究所附属机构后，他与 Gaston Ramon 一起研究光滑和粗糙 LPS。此外，他与 Albert Delaunay 一起研究外毒素和抗体（Abs）的形成。1940 年，他被提名为巴斯德研究所的助理所长。他开始研究细菌的 DNA 和 RNA，并首次提出 RNA 如何适应基因功能的假说。1947 年，他第二次搬到斯特拉斯堡，担任生物化学教授。在他 54 岁英年早逝后，法国科学院哀悼他的离去，并承认他是他们杰出的生化学、微生物学、免疫学和分子生物学大师之一。
