Endocrine Oncology, Erasmus MC, Rotterdam, The Netherlands.
Gynecol Endocrinol. 2020 Mar;36(3):213-217. doi: 10.1080/09513590.2019.1683823. Epub 2019 Nov 1.
Clémentine Delait Clattaux (1865-1934), the Bearded Woman from Thaon-les-Vosges, France, did not suffer from her extreme hirsutism, but used it to her advantage. Her beard started to grow when she turned 18 and at the age of 25 she decided to stop shaving her beard and let it grow. She had regular menstrual cycles between ages 12 and 35. She was diagnosed with signs and symptoms of hyperandrogenism like hirsutism, impressive strength and muscularity and a deep voice, but also with morbid obesity. She never gave birth to a child. At the age of 39, she was officially allowed by the French Government to wear man's clothes. She suffered from rheumatism and died because of a stroke. The most probable cause of her hirsutism was polycystic ovary syndrome. Alternatively, an incomplete block in the adrenal steroid synthesis, like nonclassical 21-hydroxylase deficiency can be considered.
克莱门汀·德莱泰·克拉托(1865-1934 年),来自法国绍通-勒沃佐的“须女”,她并没有因自己的多毛症而受苦,反而利用这一点获益。她从 18 岁开始长胡须,25 岁时决定不再刮胡子,让它继续生长。在 12 岁到 35 岁之间,她的月经周期正常。她被诊断出患有高雄激素血症的迹象和症状,如多毛症、显著的力量和肌肉发达以及深沉的嗓音,但也患有病态肥胖。她从未生育过孩子。39 岁时,法国政府正式允许她穿男装。她患有风湿病,因中风去世。她多毛症最可能的原因是多囊卵巢综合征。或者,可以考虑肾上腺类固醇合成不完全受阻,如非经典 21-羟化酶缺乏症。