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减重手术后的实验室检查:是否过度和冗余?

Post-bariatric surgery lab tests: are they excessive and redundant?

机构信息

Department of Surgery, Houston Methodist, 6550 Fannin Street, Smith Tower, Suite 1601, Houston, TX, 77030, USA.

Center for Outcomes Research and Department of Surgery, Houston Methodist, Houston, TX, USA.

出版信息

Surg Endosc. 2020 Oct;34(10):4626-4631. doi: 10.1007/s00464-019-07216-9. Epub 2019 Nov 1.

Abstract

INTRODUCTION

Following bariatric surgery, ongoing postoperative testing is required to measure nutritional deficiencies; the purpose of this study was to quantify the prevalence of these nutritional deficiencies based on two-year follow-up tests at recommended time points.

METHODS AND PROCEDURES

A retrospective data analysis was conducted of all laboratory tests for bariatric patients who underwent surgery between May 2016 and January 2018 with available lab data (n = 397). Results for nine different nutritional labs were categorized into six recommended postoperative time periods based on time elapsed since the procedure date. Binary variables were created for each laboratory result to calculate descriptive statistics of abnormalities for each lab test over time and used in the individual GEE logistic regression models. Grouped logistic regression examined the total nutritional deficiencies of the nine combined nutrients considering total available labs.

RESULTS

Multiple lab tests indicated a very low frequency of abnormalities (e.g., Vitamin A, Vitamin B12, Copper, and Folate). Many of the nine included nutritional labs had an average deficiency of less than 10% across all time points. The grouped logistic model found preoperative nutritional deficiency to be predictive of postoperative nutritional deficiency (OR 3.70, p < 0.001).

CONCLUSIONS

We found the vast majority of routine lab test results to be normal at multiple time points. Current practice can add up to significant lab expenses over time. The frequency of postoperative testing in this population may be redundant and of very little value. Unnecessary follow-up laboratory testing costs the patients and the health care system in both time and resources. Patients with preoperative deficiencies appear to be at higher risk for nutritional deficiencies when compared to bariatric surgery patients that did not have preoperative nutritional deficiencies. Future research should focus on defining cost effective postoperative lab testing guidelines for at risk bariatric patients.

摘要

简介

减重手术后需要进行持续的术后检测以衡量营养缺乏情况;本研究旨在根据推荐时间点的两年随访检测结果,量化这些营养缺乏的发生率。

方法和程序

对 2016 年 5 月至 2018 年 1 月间接受手术且有实验室数据的所有减重患者(n=397)进行回顾性数据分析。根据手术日期后时间将 9 种不同营养实验室的结果分为 6 个推荐的术后时间区间。为每个实验室结果创建二项变量,以计算每个实验室测试随时间的异常情况描述性统计数据,并在单独的 GEE 逻辑回归模型中使用。分组逻辑回归考虑了所有可用实验室,研究了 9 种组合营养素的总营养缺乏情况。

结果

多项实验室检测表明异常情况非常少见(例如,维生素 A、维生素 B12、铜和叶酸)。在所有时间点,包括的九个营养实验室中有许多平均缺乏不到 10%。分组逻辑模型发现术前营养缺乏是术后营养缺乏的预测因素(OR 3.70,p < 0.001)。

结论

我们发现大多数常规实验室检测结果在多个时间点均正常。随着时间的推移,现行实践可能会导致大量实验室费用的增加。该人群的术后检测频率可能是多余的,且价值非常有限。不必要的后续实验室检测既浪费了患者的时间和资源,也增加了医疗保健系统的负担。与没有术前营养缺乏的减重手术患者相比,术前有缺陷的患者似乎有更高的营养缺乏风险。未来的研究应集中在为有风险的减重患者制定具有成本效益的术后实验室检测指南上。

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