School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Cancer Immunol Immunother. 2020 Feb;69(2):245-253. doi: 10.1007/s00262-019-02424-7. Epub 2019 Nov 1.
Schwann cells are the principal glial cells of the peripheral nervous system which maintain neuronal homeostasis. Schwann cells support peripheral nerve functions and play a critical role in many pathological processes including injury-induced nerve repair, neurodegenerative diseases, infections, neuropathic pain and cancer. Schwann cells are implicated in a wide range of diseases due, in part, to their ability to interact and modulate immune cells. We discuss the accumulating examples of how Schwann cell regulation of the immune system initiates and facilitates the progression of various diseases. Furthermore, we highlight how Schwann cells may orchestrate an immunosuppressive tumor microenvironment by polarizing and modulating the activity of the dendritic cells.
许旺细胞是外周神经系统的主要神经胶质细胞，维持神经元内环境稳定。许旺细胞支持周围神经功能，在多种病理过程中发挥关键作用，包括损伤诱导的神经修复、神经退行性疾病、感染、神经病理性疼痛和癌症。许旺细胞与多种疾病有关，部分原因是它们能够与免疫细胞相互作用并调节免疫细胞。我们讨论了越来越多的例子，说明许旺细胞如何调节免疫系统，从而引发和促进各种疾病的进展。此外，我们还强调了许旺细胞如何通过极化和调节树突状细胞的活性来协调免疫抑制性肿瘤微环境。
