多不饱和脂肪酸与阿尔茨海默病风险：一项孟德尔随机化研究。
Polyunsaturated fatty acids and risk of Alzheimer's disease: a Mendelian randomization study.
机构信息
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Nobels väg 12A, 17 156, Stockholm, Sweden.
Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.
出版信息
Eur J Nutr. 2020 Jun;59(4):1763-1766. doi: 10.1007/s00394-019-02126-x. Epub 2019 Nov 1.
PURPOSE
Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer's disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis.
METHODS
We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of n-6 PUFAs (linoleic acid, arachidonic acid) and n-3 PUFAs (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid), and the corresponding data for AD from a genome-wide association meta-analysis of 63,926 individuals (21,982 diagnosed AD cases, 41,944 controls).
RESULTS
None of the genetically predicted PUFAs was significantly associated with AD risk; odds ratios (95% confidence interval) per 1 SD increase in PUFA levels were 0.98 (0.93, 1.03) for linoleic acid, 1.01 (0.98, 1.05) for arachidonic acid, 0.96 (0.88, 1.06) for alpha-linolenic acid, 1.03 (0.93, 1.13) for eicosapentaenoic acid, 1.03 (0.97, 1.09) for docosapentaenoic acid, and 1.01 (0.81, 1.25) for docosahexaenoic acid.
CONCLUSIONS
This study did not support the hypothesis that PUFAs decrease AD risk.
目的
观察性研究表明，多不饱和脂肪酸（PUFAs）可能降低阿尔茨海默病（AD）的风险。在本研究中，我们使用孟德尔随机化分析来检验这一假设。
方法
我们使用了与血浆中 n-6 PUFAs（亚油酸、花生四烯酸）和 n-3 PUFAs（α-亚麻酸、二十碳五烯酸、二十二碳五烯酸、二十二碳六烯酸）水平相关的单核苷酸多态性的汇总统计数据，以及来自 63926 个人的全基因组关联荟萃分析的 AD 数据（21982 例确诊 AD 病例，41944 例对照）。
结果
没有一种遗传预测的 PUFAs 与 AD 风险显著相关；每增加 1 SD 的 PUFA 水平，AD 的比值比（95%置信区间）分别为亚油酸 0.98（0.93，1.03）、花生四烯酸 1.01（0.98，1.05）、α-亚麻酸 0.96（0.88，1.06）、二十碳五烯酸 1.03（0.93，1.13）、二十二碳五烯酸 1.03（0.97，1.09）和二十二碳六烯酸 1.01（0.81，1.25）。
结论
本研究不支持 PUFAs 降低 AD 风险的假设。
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