多不饱和脂肪酸与神经性厌食症风险：一项孟德尔随机化研究。

Polyunsaturated fatty acids and risk of anorexia nervosa: A Mendelian randomization study.

作者信息

Nomura Miho, Tanaka Kotone, Banno Yukika, Hara Risako, Asami Momoko, Otsuka Tatsui, Tomata Yasutake

机构信息

School of Nutrition and Dietetics, Faculty of Health and Social Services, Kanagawa University of Human Services, Yokosuka, Japan.

Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan.

出版信息

J Affect Disord. 2023 Jun 1;330:245-248. doi: 10.1016/j.jad.2023.03.016. Epub 2023 Mar 11.

DOI:10.1016/j.jad.2023.03.016

PMID:36907461

Abstract

PURPOSE

Observational studies have suggested that polyunsaturated fatty acids (PUFAs) decrease the risk of anorexia nervosa (AN). In the present study, we examined this hypothesis using a Mendelian randomization analysis.

METHODS

We used summary statistics for single-nucleotide polymorphisms associated with plasma levels of n-6 (linoleic acid and arachidonic acid) and n-3 PUFAs (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) and the corresponding data for AN from a genome-wide association meta-analysis of 72,517 individuals (16,992 diagnosed AN cases and 55,525 controls).

RESULTS

None of the genetically predicted PUFAs were significantly associated with the risk of AN; odds ratios (95 % confidence interval) per 1 standard deviation increase in PUFA levels were 1.03 (0.98, 1.08) for linoleic acid, 0.99 (0.96, 1.03) for arachidonic acid, 1.03 (0.94, 1.12) for alpha-linolenic acid, 0.98 (0.90, 1.08) for eicosapentaenoic acid, 0.96 (0.91, 1.02) for docosapentaenoic acid, and 1.01 (0.90, 1.36) for docosahexaenoic acid.

LIMITATION

Only two types of fatty acids (LA and DPA) can be used for pleiotropy tests using the MR-Egger intercept test.

CONCLUSION

This study does not support the hypothesis that PUFAs decrease the risk of AN.

摘要

目的

观察性研究表明，多不饱和脂肪酸（PUFA）可降低神经性厌食症（AN）的风险。在本研究中，我们使用孟德尔随机化分析来检验这一假设。

方法

我们使用了与血浆n-6（亚油酸和花生四烯酸）和n-3多不饱和脂肪酸（α-亚麻酸、二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸）水平相关的单核苷酸多态性的汇总统计数据，以及来自72517名个体（16992例确诊AN病例和55525例对照）的全基因组关联荟萃分析中AN的相应数据。

结果

基因预测的多不饱和脂肪酸均与AN风险无显著关联；多不饱和脂肪酸水平每增加1个标准差的优势比（95%置信区间），亚油酸为1.03（0.98，1.08），花生四烯酸为0.99（0.96，1.03），α-亚麻酸为1.03（0.94，1.12），二十碳五烯酸为0.98（0.90，1.08），二十二碳五烯酸为0.96（0.91，1.02），二十二碳六烯酸为1.01（0.90，1.36）。