Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, 13083-970, Brazil; Department of Biology, CESAM, University of Aveiro, Aveiro, 3810-193, Portugal.
Department of Biology, CESAM, University of Aveiro, Aveiro, 3810-193, Portugal.
Environ Pollut. 2020 Jan;256:113484. doi: 10.1016/j.envpol.2019.113484. Epub 2019 Oct 24.
The widespread production and use of silver nanomaterials (AgNMs) in consumer and medical products have been raising environmental concerns. Once in the environment, the soil is one of the major sinks of AgNMs due to e.g. sewage sludge applications, and invertebrates are directly exposed. In this study, we investigate the potential of N-acetylcysteine (NAC) to reduce the toxic effects of Ag NM300 K (and AgNO) on the soil invertebrate Enchytraeus crypticus. Ag NM300 K induces mortality, reproduction impairment, and avoidance. The addition of NAC to the soil showed a remarkable reduction in the toxicity of Ag, indicating that NAC can act as a detoxifying agent for terrestrial organisms exposed to Ag materials. That the reduction in toxicity likely is caused by thiol groups, was confirmed by GSH and GSSH studies. Identifying the mechanisms and hence alternatives that allow the recovery of contaminated soils is an important mitigation measure to promote environmental safety and reduce the associated risks to human health. Further, it may inform on strategies to implement in safe-by-design industry development.
银纳米材料（AgNMs）在消费和医疗产品中的广泛生产和使用引起了人们对环境的关注。一旦进入环境，土壤是 AgNMs 的主要汇之一，例如通过污水污泥的应用，而无脊椎动物则直接暴露于其中。在这项研究中，我们研究了 N-乙酰半胱氨酸（NAC）是否可以降低 Ag NM300K（和 AgNO）对土壤无脊椎动物秀丽隐杆线虫的毒性影响。Ag NM300K 会导致死亡率、繁殖能力受损和回避行为。向土壤中添加 NAC 显著降低了 Ag 的毒性，表明 NAC 可以作为暴露于 Ag 材料的陆地生物的解毒剂。通过 GSH 和 GSSH 研究证实，毒性降低可能是由巯基引起的。确定允许受污染土壤恢复的机制和替代方法是促进环境安全和降低相关人类健康风险的重要缓解措施。此外，这可能为实施安全设计的工业发展战略提供信息。
