弱精子症：细胞和分子影响因素及治疗策略

Asthenozoospermia: Cellular and molecular contributing factors and treatment strategies.

作者信息

Shahrokhi Seyedeh Zahra, Salehi Peyman, Alyasin Atieh, Taghiyar Sana, Deemeh Mohammad Reza

机构信息

Department of Laboratory Medicine, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Infertility Center, Shahid Beheshti Hospital, Isfahan, Iran.

出版信息

Andrologia. 2020 Mar;52(2):e13463. doi: 10.1111/and.13463. Epub 2019 Nov 3.

DOI:10.1111/and.13463

PMID:31680293

Abstract

Semen sample with poor sperm motility, which called asthenozoospermia, is considered as one of the main factors contributing to male infertility. Recognition of the cellular and molecular pathways contributing to sperm motility reduction may lead to applying novel treatment strategies for overcoming low sperm motility in asthenozoospermia individuals. In this review, we intend to discuss the main causes of sperm motility reduction in asthenozoospermia and some treatment strategies used to overcome low sperm motility.

摘要

精子活力差的精液样本，即所谓的弱精子症，被认为是导致男性不育的主要因素之一。认识到导致精子活力降低的细胞和分子途径，可能会带来新的治疗策略，以克服弱精子症患者精子活力低的问题。在这篇综述中，我们打算讨论弱精子症中精子活力降低的主要原因以及一些用于克服精子活力低的治疗策略。