Pearcey R, Calvert R, Mehta A
University Department of Radiotherapy, Cookridge Hospital, Leeds, UK.
Cancer Chemother Pharmacol. 1988;22(4):353-5. doi: 10.1007/BF00254245.
The disposition of ifosfamide was investigated in nine patients receiving a total of 23 72-h infusions. There was no linear relationship between steady-state plasma concentrations and either vomiting or CNS toxicity. The steady-state plasma concentrations were reproducible within patients, but there was a wide variation between patients. The progress of the disease did not affect the disposition of ifosfamide.
