通过气液色谱法估算人静脉注射环磷酰胺的药代动力学。
Pharmacokinetics of intravenous cyclophosphamide in man, estimated by gas-liquid chromatography.
作者信息
Juma F D, Rogers H J, Trounce J R, Bradbrook I D
出版信息
Cancer Chemother Pharmacol. 1978;1(4):229-31. doi: 10.1007/BF00257155.
PMID:750109
Abstract
A simple gas chromatographic assay utilising alkali flame ionisation detection is described for the estimation of cyclophosphamide as its trifluoroacetate derivative from plasma. Examination of five patients following intravenous cyclophosphamide gave values of 8.9 h (SD 2.7) for the half-life and 0.061 liters/h/kg (SD 0.011) for whole-body clearance of the drug.
摘要
描述了一种利用碱火焰离子化检测的简单气相色谱分析法，用于从血浆中测定环磷酰胺的三氟乙酸酯衍生物。对5例静脉注射环磷酰胺后的患者进行检测，得出该药物的半衰期为8.9小时（标准差2.7），全身清除率为0.061升/小时/千克（标准差0.011）。
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