Yan Huimin, Duan Xin, Collins Kelsey H, Springer Luke E, Guilak Farshid, Wickline Samuel A, Rai M Farooq, Pan Hua, Pham Christine T N
Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO.
Precis Nanomed. 2019;2(1):245-248. doi: 10.33218/prnano2(1).181129.1. Epub 2019 Jan 12.
Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis . Herein, we demonstrate that the suppression of NF-κB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF-κB nanotherapy mitigates both structural and pain-related outcomes, which in turn may impact the progression of post-traumatic osteoarthritis.
关节损伤后的炎症会引发关节反应，最终导致骨关节炎的发展。通过抑制NF-κB表达来阻断炎症，已被证明可减少关节损伤诱导的软骨细胞凋亡和反应性滑膜炎。在此，我们证明抑制NF-κB p65表达也能显著减轻关节机械损伤引起的急性疼痛敏感性。这些结果表明，抗NF-κB纳米疗法的早期干预可减轻结构和疼痛相关的后果，进而可能影响创伤后骨关节炎的进展。
