Department of Analytical Chemistry, Physical Chemistry, and Chemical Engineering, University of Alcala, 28805, Madrid, Spain.
Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Chemistry. 2020 Feb 21;26(11):2309-2326. doi: 10.1002/chem.201903475. Epub 2019 Dec 20.
Micromotors are man-made nano/microscale devices capable of transforming energy into mechanical motion. The accessibility and force offered by micromotors hold great promise to solve complex biomedical challenges. This Review highlights current progress and prospects in the use of nano and micromotors for diagnosis and treatment of infectious diseases and cancer. Motion-based sensing and fluorescence switching detection strategies along with therapeutic approaches based on direct cell capture; killing by direct contact or specific drug delivery to the affected site, will be comprehensively covered. Future challenges to translate the potential of nano/micromotors into practical applications will be described in the conclusions.
微马达是一种人造的纳米/微尺度装置,能够将能量转化为机械运动。微马达提供的可达性和力为解决复杂的生物医学挑战带来了巨大的希望。这篇综述重点介绍了纳米和微马达在诊断和治疗传染病和癌症方面的最新进展和前景。将全面涵盖基于运动的传感和荧光切换检测策略,以及基于直接细胞捕获的治疗方法;通过直接接触或向受影响部位特异性药物输送来杀死细胞。在结论中,将描述将纳米/微马达的潜力转化为实际应用的未来挑战。