van der Hoorn Marie-Louise P, Lashley E E L O
LUMC, afd. Gynaecologie en Verloskunde, Leiden.
Contact: M.L.P. van der Hoorn (
Ned Tijdschr Geneeskd. 2019 Oct 24;163:D4395.
This commentary reflects on the effectiveness of progesterone in early pregnancy complications. Several studies have investigated the role of progesterone in women with bleeding in early pregnancy and in women with recurrent miscarriages. These publications suggests that first trimester use of progesterone is not effective to prevent miscarriages when there is blood loss in the first trimester, and that it is also not effective to prevent new miscarriages in women with recurrent miscarriages in their history. However, subgroup analysis tells us it might be effective to prevent new miscarriages in women with blood loss in the first trimester and three earlier miscarriages. Expert groups in the Netherlands are currently considering recommendations on the prescription of progesterone for women with early pregnancy complications.
本评论探讨了孕酮在早期妊娠并发症中的有效性。多项研究调查了孕酮在早期妊娠出血女性和复发性流产女性中的作用。这些出版物表明，孕早期使用孕酮对预防孕早期出血时的流产无效，对有复发性流产史的女性预防新的流产也无效。然而，亚组分析告诉我们，对于孕早期出血且有三次早期流产史的女性，预防新的流产可能有效。荷兰的专家小组目前正在考虑就孕早期并发症女性使用孕酮的处方提出建议。
