Department of Adolescent Psychiatry, University of Tampere and Tampere University Hospital.
FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku; Centre for Population Health Research, University of Turku and Turku University Hospital; Department of Child Psychiatry, University of Turku and Turku University Hospital.
J Psychosom Res. 2019 Dec;127:109843. doi: 10.1016/j.jpsychores.2019.109843. Epub 2019 Oct 17.
Sleep disturbances relate to altered levels of inflammatory mediators in general population, but not much is known about the associations between sleep disturbances and inflammatory mediators during pregnancy. The present exploratory study investigated whether insomnia, tiredness, general sleep quality, and insufficient sleep duration during pregnancy relate to the concentrations of maternal peripheral circulating cytokines. As sleep disturbances are frequently observed in mood disorders, the results were controlled for symptoms of depression and anxiety.
137 participants were randomly drawn from a representative FinnBrain Birth Cohort. Serum concentrations of selected cytokines were analyzed using Multiplex bead arrays from blood samples drawn at the gestational week 24. The sleep disturbances were evaluated using the Basic Nordic Sleep Questionnaire. Depressive and anxiety symptoms were measured with the Edinburgh Postnatal Depression Scale and the anxiety subscale of the self-rated Symptom Checklist 90, respectively.
Enhanced tiredness was associated with cytokine concentrations of IL-2, IL-10, IL-12, IL-13, and TNF-α. The observed associations resembled a reversed U-shaped curve rather than being linear. Having a good general sleep quality was associated with higher logarithmic cytokine concentrations of IL-2, IL-4, IL-6, IL-10, IL-12, IL-13, and IFN-γ. There was no evidence for associations between insomnia or sleep loss and cytokines.
Maternal subjective tiredness and good general sleep quality were associated with altered levels of immunological markers during pregnancy. The association was independent from symptoms of depression and anxiety.
睡眠障碍与一般人群中炎症介质水平的改变有关，但关于怀孕期间睡眠障碍与炎症介质之间的关系知之甚少。本探索性研究调查了怀孕期间的失眠、疲劳、总体睡眠质量和睡眠时间不足是否与母体外周循环细胞因子的浓度有关。由于睡眠障碍在情绪障碍中很常见，因此对抑郁和焦虑症状进行了控制。
从具有代表性的 FinnBrain 出生队列中随机抽取了 137 名参与者。使用 Multiplex bead arrays 从妊娠 24 周时抽取的血液样本中分析了选定细胞因子的血清浓度。使用 Basic Nordic Sleep Questionnaire 评估睡眠障碍。使用 Edinburgh Postnatal Depression Scale 和自评 Symptom Checklist 90 的焦虑分量表分别测量抑郁和焦虑症状。
增强的疲劳与 IL-2、IL-10、IL-12、IL-13 和 TNF-α 的细胞因子浓度相关。观察到的关联类似于倒 U 形曲线，而不是线性关系。良好的总体睡眠质量与较高的对数细胞因子浓度的 IL-2、IL-4、IL-6、IL-10、IL-12、IL-13 和 IFN-γ 相关。没有证据表明失眠或睡眠不足与细胞因子有关。
母体主观疲劳和良好的总体睡眠质量与怀孕期间免疫标志物水平的改变有关。这种关联独立于抑郁和焦虑症状。
